Trial reportEnvironmental health perspectives2015
Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: a crossover study of healthy young volunteers.
Trial report in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 118 citations in OpenAlex.
- Trial
- Article
- Investigation of the Association between Long-term Ozone Exposure and Cardiovascular Disease: A Meta-Analysis Addressing Exposure Windows, Vulnerable Populations, and Spatial Variation.China CDC weekly · 2026Review
- Short-Term Exposure to Ambient Ozone and Fine Particulate Matter and Its Components Increases the Risk of In-Hospital Adverse Outcomes in Patients With Acute Myocardial Infarction: A Time-Stratified Case-Crossover Study.Journal of the American Heart Association · 2026Article
- Article
- Climate change: a critical time for respiratory health.Respiratory research & clinical practice · 2026Review
- Influence of extreme temperatures on out-of-hospital cardiac arrest cases in Hungary: a national time-series analysis.Resuscitation plus · 2026Article
- Causal Association of Prenatal Ozone Exposure with Impaired Lung Function in Childhood.Environment & health (Washington, D.C.) · 2025Article
- Heat Exposure Changes Lung Function, Biomarkers of Airway Injury, and Airway Microbiota: A Randomized, Crossover Trial.Environment & health (Washington, D.C.) · 2025Article
- Modifying effects of PMScientific reports · 2025Article
- Short-term effects of air pollution on childhood respiratory symptoms in general practice: a time-series analysis.BMJ paediatrics open · 2025Article
- Respiratory Health Impacts from Natural Disasters and Other Extreme Weather Events: The Role of Environmental Stressors on Asthma and Allergies.Current allergy and asthma reports · 2025Review
- Short-Term Effect of Ozone Exposure on Small Airway Function in Adult Asthma Patients with PMToxics · 2025Article
- Effect of Ozone Exposure on Cardiovascular and Cerebrovascular Disease Mortality in the Elderly.Toxics · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- The emerging role of fibrin(ogen) in cardiovascular disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Review
- Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation.Frontiers in science · 2024Article
- The effect modification of PMEnvironmental health and preventive medicine · 2024Article
- Accelerated aging and altered subclinical response to ozone exposure in young, healthy adults.Environmental epigenetics · 2024Article
- Association between long-term exposure to ambient air pollution and lesion ischemia in patients with atherosclerosis.Atherosclerosis · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrends in climate suggest that extreme weather events such as heat waves will become more common. High levels of the gaseous pollutant ozone are associated with elevated temperatures. Ozone has been associated with respiratory diseases as well as cardiovascular morbidity and mortality and can reduce lung function and alter systemic markers of fibrinolysis. The interaction between ozone and temperature is unclear.
methodsSixteen healthy volunteers were exposed in a randomized crossover study to 0.3 ppm ozone and clean air for 2 hr at moderate (22°C) temperature and again at an elevated temperature (32.5°C). In each case lung function was performed and blood taken before and immediately after exposure and the next morning.
resultsOzone exposure at 22°C resulted in a decrease in markers of fibrinolysis the next day. There was a 51.8% net decrease in PAI-1 (plasminogen activator inhibitor-1), a 12.1% net decrease in plasminogen, and a 17.8% net increase in D-dimer. These significantly differed from the response at 32.5°C, where there was a 44.9% (p = 0.002) and a 27.9% (p = 0.001) increase in PAI-1 and plasminogen, respectively, and a 12.5% (p = 0.042) decrease in D-dimer. In contrast, decrements in lung function following ozone exposure were comparable at both moderate and elevated temperatures (forced expiratory volume in 1 sec, -12.4% vs. -7.5%, p > 0.05). No changes in systemic markers of inflammation were observed for either temperature.
conclusionOzone-induced systemic but not respiratory effects varied according to temperature. Our study suggests that at moderate temperature ozone may activate the fibrinolytic pathway, while at elevated temperature ozone may impair it. These findings provide a biological basis for the interaction between temperature and ozone on mortality observed in some epidemiologic studies.
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