Trial reportGenetic testing and molecular biomarkers2015
Association of genetic polymorphisms of EGFR with glioma in a Chinese population.
Trial report in Genetic testing and molecular biomarkers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population.Scientific reports · 2022Article
- Epidermal Growth Factor Receptor (EGFR) Gene Polymorphism May be a Modifier for Cadmium Kidney Toxicity.Genes · 2021Article
- The impact ofGland surgery · 2020Article
- Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- The Impact of EGFR Gene Polymorphisms on the Risk of Alzheimer's Disease in a Chinese Han Population: A Case-Controlled Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The Association between Epidermal Growth Factor Receptor (Biomolecules · 2018Article
- Associations between EGFR gene polymorphisms and susceptibility to glioma: a systematic review and meta-analysis from GWAS and case-control studies.Oncotarget · 2017Article
- A case-control study of the association between theOncotarget · 2017Article
- Effect of epidermal growth factor receptor gene polymorphisms on prognosis in glioma patients.Oncotarget · 2016Article
- An integrated transcriptomic and computational analysis for biomarker identification in human glioma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- The Effects and Molecular Mechanisms of MiR-106a in Multidrug Resistance Reversal in Human Glioma U87/DDP and U251/G Cell Lines.PloS one · 2015Article
- Association between EGFR polymorphisms and the risk of lung cancer.International journal of clinical and experimental pathology · 2015Article
- Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.American journal of cancer research · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSeveral studies indicated that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene were associated with glioma risk. However, the relationship between EGFR genetic polymorphisms and glioma remains unclear in the Chinese population.
methodsWe designed a case-control study by selecting 300 histologically confirmed adult glioma patients and 300 cancer-free controls to analyze the distribution of EGFR genotype. Two single-nucleotide polymorphisms, rs730437 and rs1468727, were genotyped by using the polymerase chain reaction-restriction fragment length polymorphism method.
resultsWe found that the CC genotype of rs1468727 was more common in the glioma group than in the control group (p=0.021). We also found that the C allele frequency was higher in the glioma group than that in the control group (p=0.005; odds ratio [OR]=1.38, 95% confidence interval [CI]: 1.101-1.740). For rs730437, we found both the AA genotype (p=0.011) and A allele frequency (p=0.003; OR=0.703; 95% CI: 0.558-0.886) were significantly lower in the glioma patients than in the control subjects, respectively. Haplotype analysis showed that the A T haplotype frequency was higher in the control group than in the glioma group (p=0.005; OR=0.722; 95% CI: 0.575-0.908). However, the CC haplotype frequency was higher in the glioma group than in the control group (p=0.003; OR=1.423; 95% CI: 1.129-1.793).
conclusionOur study indicates that polymorphisms in the EGFR gene are associated with glioma susceptibility in the Chinese population.
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