ArticleStem cell research2015
Transcriptome analysis of chicken ES, blastodermal and germ cells reveals that chick ES cells are equivalent to mouse ES cells rather than EpiSC.
Article in Stem cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed.
- The chicken retrovirus-like geneiScience · 2026Article
- Analysis of Transcriptome and Differentially Expressed Genes in Chicken Primordial Germ Cells.Animals : an open access journal from MDPI · 2026Article
- Comparative genomics reveals common diversity and adaptation to harsh environments in the Arabian Peninsula indigenous chickens.Animal genetics · 2025Article
- Establishment of chicken muscle and adipogenic cell cultures for cultivated meat production.Frontiers in nutrition · 2025Article
- The Effect of Inhibiting the Wingless/Integrated (WNT) Signaling Pathway on the Early Embryonic Disc Cell Culture in Chickens.Animals : an open access journal from MDPI · 2024Article
- Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals.Epigenetics & chromatin · 2024Article
- FEZF2 and AIRE1: An Evolutionary Trade-off in the Elimination of Auto-reactive T Cells in the Thymus.Journal of molecular evolution · 2024Article
- Review
- Ascorbic acid and all-trans retinoic acid promote proliferation of chicken blastoderm cells (cBCs) by mediating DNA demethylation.In vitro cellular & developmental biology. Animal · 2022Article
- Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.Scientific reports · 2022Article
- Storage temperature dictates the ability of chicken embryos to successfully resume development by regulating expression of blastulation and gastrulation genes.Frontiers in physiology · 2022Article
- Avian Embryonic Culture: A Perspective ofFrontiers in physiology · 2022Review
- Chick fetal organ spheroids as a model to study development and disease.BMC molecular and cell biology · 2021Article
- Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells.Journal of animal science and biotechnology · 2021Article
- Transcriptome Profiling of the Ovarian Cells at the Single-Cell Resolution in Adult Asian Seabass.Frontiers in cell and developmental biology · 2021Article
- Transcriptome Sequencing and Comparative Analysis of Amphoteric ESCs and PGCs in Chicken (Animals : an open access journal from MDPI · 2020Article
- Dynamics of the transcriptome during chicken embryo development based on primordial germ cells.BMC research notes · 2020Article
- Mammalian germ cells are determined after PGC colonization of the nascent gonad.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.Development (Cambridge, England) · 2019Article
- In vitro culture and characterization of duck primordial germ cells.Poultry science · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Pluripotent Embryonic Stem cell (ESC) lines can be derived from a variety of sources. Mouse lines derived from the early blastocyst and from primordial germ cells (PGCs) can contribute to all somatic lineages and to the germ line, whereas cells from slightly later embryos (EpiSC) no longer contribute to the germ line. In chick, pluripotent ESCs can be obtained from PGCs and from early blastoderms. Established PGC lines and freshly isolated blastodermal cells (cBC) can contribute to both germinal and somatic lineages but established lines from the former (cESC) can only produce somatic cell types. For this reason, cESCs are often considered to be equivalent to mouse EpiSC. To define these cell types more rigorously, we have performed comparative microarray analysis to describe a transcriptomic profile specific for each cell type. This is validated by real time RT-PCR and in situ hybridisation. We find that both cES and cBC cells express classic pluripotency-related genes (including cPOUV/OCT4, NANOG, SOX2/3, KLF2 and SALL4), whereas expression of DAZL, DND1, DDX4 and PIWIL1 defines a molecular signature for germ cells. Surprisingly, contrary to the prevailing view, our results also suggest that cES cells resemble mouse ES cells more closely than mouse EpiSC.
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