Observational studyPloS one2014
Relationship between immune parameters and organ involvement in children with Henoch-Schonlein purpura.
Observational study in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Infectious triggers in IgA vasculitis in children: current evidence, causal attribution and immunopathogenic mechanisms.Rheumatology international · 2026Review
- Population-specific patterns of IgE sensitization in Northwest China.Clinics (Sao Paulo, Brazil) · 2026Article
- Development and validation of a clinical prediction model for gastrointestinal hemorrhage in pediatric IgA vasculitis.BMC pediatrics · 2026Observational
- Modern biomarkers in IgA vasculitis with nephritis in children.Central-European journal of immunology · 2025Review
- Oral microbiota imbalance: A predisposing factor for Henoch-Schönlein Purpura in children.Heliyon · 2024Article
- Causal relationships between gut microbiota, immune cell, and Henoch-Schönlein Purpura: a two-step, two-sample Mendelian randomization study.Frontiers in immunology · 2024Article
- The comparisons of vitamin D3 levels in IgA vasculitis across different subgroups and healthy children: a comparative study.Translational pediatrics · 2023Article
- Identification of key genes and imbalance of immune cell infiltration in immunoglobulin A associated vasculitis nephritis by integrated bioinformatic analysis.Frontiers in immunology · 2023Article
- Risk factors associated with recurrence of Henoch-Schonlein purpura: a retrospective study.Frontiers in pediatrics · 2023Article
- IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers.Frontiers in immunology · 2022Review
- Characteristics of immune function in the acute phase of Henoch-Schönlein purpura.Clinical rheumatology · 2021Article
- Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients.BMC immunology · 2020Article
- Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis.Clinical rheumatology · 2019Article
- Beneficial Effects of Qingzixiaoban Granule on Henoch-Schönlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.Italian journal of pediatrics · 2018Article
- Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases.BMC pediatrics · 2018Article
- [Research advances in immunological pathogenesis of immunoglobulin A vasculitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Review
- Application value of laboratory indexes in the differential diagnosis of Henoch-Schoenlein purpura.Zeitschrift fur Rheumatologie · 2017Article
- [Changes in 25-hydroxyvitamin D3 level in children with Henoch-Schönlein purpura].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.The American journal of case reports · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Henoch-Schonlein purpura (HSP) is the most common type of connective tissue diseases which increasingly occurs in children in recent years and its pathogenesis remains unclear. In order to explore the immune parameters and underlying pathogenesis mechanism of children with HSP, the study involved 1232 patients with HSP having different clinical symptoms and their laboratory indicators were evaluated. Th1/Th2 imbalance and overactivity of Th2 cells can cause increase in the synthesis and release of immunoglobulins in children with HSP. The number of red blood cells and white blood cells in urine was directly proportional to the level of IgA and inversely proportional to the level of serum complements (C3 and C4). Activation of these complements caused by immunoglobulin in patients with HSP plays an important role in renal injury. The urinary protein content in children with HSP along with proteinuria was positively correlated with IgE level, and IgE mediated type 1 hypersensitivity can cause increase in capillary permeability and weakened the charge barrier; hence, it could be considered as one of the causes of proteinuria in HSP. Additionally, the NK cells percentage was reduced and impaired immune function of NK cells were related to the immune injury of the digestive tract and kidney.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.