ArticleSexual health2015
Evolution of the syphilis epidemic among men who have sex with men.
Article in Sexual health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Reliability of administrative data to identify sexually transmitted infections for population health: a systematic review.BMJ health & care informatics · 2019Pooled it
- Incognito Standardized Patients to Assess Physician Awareness and Capacity to Recognize Primary Syphilis Presentation in Chinese STI Clinics.Sexually transmitted diseases · 2026Article
- Congenital Syphilis: From Near-Elimination to Crisis.American journal of public health · 2026Article
- The Role of Traditional and Reverse Algorithms in the Diagnosis of Syphilis in HIV-Infected Individuals: A Case Study on Istanbul.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Clinical and Laboratory Characteristics, Diagnosis, and Treatment of Patients with Neurosyphilis in Emergency Department: A Retrospective Study of 12 Patients.Infection and drug resistance · 2024Article
- HIV, syphilis, and hepatitis B virus infection and male circumcision in five Sub-Saharan African countries: Findings from the Population-based HIV Impact Assessment surveys, 2015-2019.PLOS global public health · 2023Article
- Community perspectives on ideal bacterial STI testing services for gay, bisexual, and other men who have sex with men in Toronto, Canada: a qualitative study.BMC health services research · 2022Article
- Correlates of prevalent syphilis infection among men who have sex with men (MSM) living with HIV attending the HIV clinic in Trinidad.PloS one · 2022Article
- Isolated Cranial Nerve VI Palsy and Neurosyphilis: A Case Report and Review of Related Literature.IDCases · 2022Article
- Simple-to-use nomogram for predicting the risk of syphilis among MSM in Guangdong Province: results from a serial cross-sectional study.BMC infectious diseases · 2021Article
- Identification of a Human Immunodeficiency Virus Type 1 and Neurosyphilis Cluster in Vermont.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- A case of a pseudoneoplastic primary syphilis chancre on the neck.JAAD case reports · 2021Article
- The Social Geography of Partner Selection in Toronto, Canada: A Qualitative Description of "Convection Mixing".Archives of sexual behavior · 2020Article
- Neurosyphilis: Old Disease, New Implications for Emergency Physicians.Clinical practice and cases in emergency medicine · 2020Article
- Resurgence of Syphilis in the United States: An Assessment of Contributing Factors.Infectious diseases · 2019Review
- Syphilis Trends in the Central Savannah River Area (CSRA) of Georgia and South Carolina, USA.Journal of clinical medicine · 2018Article
- Conceptualizing Geosexual Archetypes: Mapping the Sexual Travels and Egocentric Sexual Networks of Gay and Bisexual Men in Toronto, Canada.Sexually transmitted diseases · 2018Article
- An Update on the Global Epidemiology of Syphilis.Current epidemiology reports · 2018Article
- Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men.Expert review of anti-infective therapy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Syphilis has existed for millenni, but its epidemiology was only recently linked to men who have sex with men (MSM) after the introduction of penicillin in the 1940s; the syphilis epidemic became concentrated within the MSM community in subsequent decades. The HIV/AIDS epidemic in the 1980s led to a surge of new syphilis cases and revealed the potentiation between HIV and syphilis, as evidenced by a shift in the natural history of neurosyphilis. In response, MSM revolutionised their sexual behaviour by implementing community-driven seroadaptive strategies to stem HIV transmission. The Centers for Disease Control in the US called for the elimination of syphilis in the late 1990s since the rates had fallen sharply but this effort was overtaken by a resurgence of global outbreaks among MSM in the 2000s, many of which were linked to methamphetamine use and sexual networking websites. Syphilis remains highly prevalent today, especially among MSM and individuals infected with HIV, and it continues to present a significant public health conundrum. Innovative syphilis prevention strategies are warranted. MSM engaging in high-risk behaviour such as condomless anal receptive intercourse, sex with multiple partners or recreational drug use should be routinely screened for syphilis infection; they should also be counselled about the limits of seroadaptive behaviours and HIV pre-exposure prophylaxis as they relate to syphilis transmission.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.