ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2015
Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- The genomic architecture of antimalarial drug resistance.Briefings in functional genomics · 2019Review
- Checks and balances? DNA replication and the cell cycle in Plasmodium.Parasites & vectors · 2018Review
- Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.Parasite (Paris, France) · 2018Review
- Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance.BMC genomics · 2017Article
- Extreme mutation bias and high AT content in Plasmodium falciparum.Nucleic acids research · 2017Article
- Genome WideFrontiers in microbiology · 2017Article
- Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ.Scientific reports · 2016Article
- Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions.Scientific reports · 2016Article
- Comparative assessment on the prevalence of mutations in the Plasmodium falciparum drug-resistant genes in two different ecotypes of Odisha state, India.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.Molecular biology and evolution · 2016Article
- Plasmodium falciparum: multifaceted resistance to artemisinins.Malaria journal · 2016Review
- South-East Asian strains ofF1000Research · 2016Article
- Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites.PloS one · 2016Article
- Malaria ecology along the Thailand-Myanmar border.Malaria journal · 2015Article
Corrections and comments
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Authors and funding
14 authors at 11 institutions in 8 countries.
Funding
Abstract
Multiple transcontinental waves of drug resistance in Plasmodium falciparum have originated in Southeast Asia before spreading westward, first into the rest of Asia and then to sub-Saharan Africa. In vitro studies have suggested that hypermutator P. falciparum parasites may exist in Southeast Asia and that an increased rate of acquisition of new mutations in these parasites may explain the repeated emergence of drug resistance in Southeast Asia. This study is the first to test the hypermutator hypothesis using field isolates. Using genome-wide SNP data from human P. falciparum infections in Southeast Asia and West Africa and a test for relative rate differences we found no evidence of increased relative substitution rates in P. falciparum isolates from Southeast Asia. Instead, we found significantly increased substitution rates in Mali and Bangladesh populations relative to those in populations from Southeast Asia. Additionally we found no association between increased relative substitution rates and parasite clearance following treatment with artemisinin derivatives.
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