ArticleInternational journal of environmental research and public health2014
Alanine aminotransferase within reference range is associated with metabolic syndrome in middle-aged and elderly Chinese men and women.
Article in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Triglyceride glucose-body mass index as a practical screening tool for metabolic dysfunction-associated steatotic liver disease in older adults: A community-based cohort study.Asia Pacific journal of clinical nutrition · 2026Article
- Metabolic Syndrome and Insulin Resistance Are Associated With Normal-Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome.Clinical endocrinology · 2025Article
- Gut microbiome is associated with metabolic syndrome accompanied by elevated gamma-glutamyl transpeptidase in men.Frontiers in cellular and infection microbiology · 2022Article
- Measurement of the Combined Levels of Serum Uric Acid and Alanine Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged 60 Years or More in Northeastern China.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Association of Inflammatory and Liver Markers with Cardiometabolic Risk Factors in Patients with Depression.Indian journal of clinical biochemistry : IJCB · 2019Article
- Association between liver function and metabolic syndrome in Chinese men and women.Scientific reports · 2017Article
- Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population.Nutrition & metabolism · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between serum ALT level within reference range (≤40 U/L) and morbidity of MetS in a large middle-aged and elderly Chinese community population.
methodsOur study was a community-based cross-sectional survey which used cluster sampling method. From November 2011 to August 2012 a total of 16,539 subjects (males 5184; females 11,355) with serum ALT levels in the normal range aged ≥40 years from Shijingshan District (Beijing, China) were included in the study. Data on demographic information, lifestyle, history of diabetes mellitus, hypertension, dyslipidemia and liver disease were collected. Body height, body weight, waist circumference, hip circumference, and blood pressure were recorded. The oral glucose tolerance test or a standard meal test and blood lipid test was performed. The determination of metabolic syndrome was according to the unified criteria published in 2009. The association between serum ALT level and metabolic syndrome was evaluated by logistic regression. The association between serum ALT level and all components of metabolic syndrome was evaluated by multiple linear regression. p < 0.05 was regarded as statistically significant.
resultsThe prevalence of metabolic syndrome was 41.4% in males and 40.6% in females. We found ALT level was positively associated with odds of metabolic syndrome after adjustment for age, smoking, and alcohol intake. The odds ratio values of MetS in the ALT quartiles 2-4 groups were 1.920 (95%CI: 1.619-2.277), 2.853 (95%CI: 2.407-3.381), and 4.171 (95%CI: 3.510-4.956) in males; 1.889 (95%CI: 1.671-2.136), 3.490 (95%CI: 3.095-3.935), and 5.593 (95%CI: 4.957-6.311) in females, respectively, compared with the ALT quartile 1 group.
conclusionsHigher serum ALT level within the reference range was associated with increased odds of MetS in middle-aged and elderly Chinese men and women.
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