ArticleMarine drugs2014
Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Identification and Biosynthesis of Tropodithietic Acid byInternational journal of molecular sciences · 2026Article
- Autecology of an oscillating population of a novel host-associatedISME communications · 2025Article
- Maribacter halichondriae sp. nov., isolated from the marine sponge Halichondria panicea, displays features of a sponge-associated life style.Antonie van Leeuwenhoek · 2024Article
- The potential to produce tropodithietic acid by Phaeobacter inhibens affects the assembly of microbial biofilm communities in natural seawater.NPJ biofilms and microbiomes · 2023Article
- Article
- The ability of Phaeobacter inhibens to produce tropodithietic acid influences the community dynamics of a microalgal microbiome.ISME communications · 2022Article
- Role is in the eye of the beholder-the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae.FEMS microbiology reviews · 2022Article
- Article
- Genome Analysis of theCurrent issues in molecular biology · 2021Article
- A Family of Nonribosomal Peptides Modulate Collective Behavior in Pseudovibrio Bacteria Isolated from Marine Sponges*.Angewandte Chemie (International ed. in English) · 2021Article
- An Analysis of Biosynthesis Gene Clusters and Bioactivity of Marine Bacterial Symbionts.Current microbiology · 2021Review
- Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential.Chembiochem : a European journal of chemical biology · 2020Review
- Changes in the Microbiome of Mariculture Feed Organisms after Treatment with a Potentially Probiotic Strain of Phaeobacter inhibens.Applied and environmental microbiology · 2020Article
- Diversity and Distribution of Bacteria Producing Known Secondary Metabolites.Microbial ecology · 2019Article
- Culturing marine bacteria from the genus Pseudoalteromonas on a cotton scaffold alters secondary metabolite production.MicrobiologyOpen · 2019Article
- Ecology and Biotechnological Potential of Bacteria Belonging to the Genus Pseudovibrio.Applied and environmental microbiology · 2018Review
- Comparative Genomics Highlights Symbiotic Capacities and High Metabolic Flexibility of the Marine Genus Pseudovibrio.Genome biology and evolution · 2018Article
- Determining the presence of asthma-related molecules and salivary contamination in exhaled breath condensate.Respiratory research · 2017Article
- Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens.Scientific reports · 2017Article
- Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis.The ISME journal · 2017Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The search for new antimicrobial compounds has gained added momentum in recent years, paralleled by the exponential rise in resistance to most known classes of current antibiotics. While modifications of existing drugs have brought some limited clinical success, there remains a critical need for new classes of antimicrobial compound to which key clinical pathogens will be naive. This has provided the context and impetus to marine biodiscovery programmes that seek to isolate and characterize new activities from the aquatic ecosystem. One new antibiotic to emerge from these initiatives is the antibacterial compound tropodithietic acid (TDA). The aim of this study was to provide insight into the bioactivity of and the factors governing the production of TDA in marine Pseudovibrio isolates from a collection of marine sponges. The TDA produced by these Pseudovibrio isolates exhibited potent antimicrobial activity against a broad spectrum of clinical pathogens, while TDA tolerance was frequent in non-TDA producing marine isolates. Comparative genomics analysis suggested a high degree of conservation among the tda biosynthetic clusters while expression studies revealed coordinated regulation of TDA synthesis upon transition from log to stationary phase growth, which was not induced by TDA itself or by the presence of the C10-acyl homoserine lactone quorum sensing signal molecule.
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