ArticleAnnals of intensive care2014
Self-reported attitudes versus actual practice of oxygen therapy by ICU physicians and nurses.
Article in Annals of intensive care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients (SAVE-O2)
Strategy to Avoid Excessive Oxygen in Major Burn Patients (SAVE-O2)
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Manual compared to automated closed-loop oxygen control strategies in hospitalised adults: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Effect of liberal or conservative oxygen therapy on the prognosis for mechanically ventilated intensive care unit patients: a meta-analysis.Sao Paulo medical journal = Revista paulista de medicinaPooled it
- Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.JAMA network open · 2025Trial
- Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation.The New England journal of medicine · 2022Trial
- Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.Intensive care medicine · 2018Trial
- Trial
- Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model.Experimental gerontology · 2024Article
- Hyperoxemia and hypoxemia impair cellular oxygenation: a study in healthy volunteers.Intensive care medicine experimental · 2024Article
- Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated.Clinical trials (London, England) · 2024Article
- The association between high-oxygen saturation and prognosis for intracerebral hemorrhage.Neurosurgical review · 2024Article
- The effect of conservative oxygen therapy on mortality in adult critically ill patients: A systematic review and meta-analysis of randomised controlled trials.Journal of the Intensive Care Society · 2023Article
- Impacts of a fraction of inspired oxygen adjustment protocol in COVID-19 patients under mechanical ventilation: A prospective cohort study.Medicina intensiva · 2023Article
- Impacts of a fraction of inspired oxygen adjustment protocol in COVID-19 patients under mechanical ventilation: A prospective cohort study.Medicina intensiva · 2023Article
- Oxygen as an Essential Medicine.Critical care clinics · 2022Review
- Outcomes and Predictors of Severe Hyperoxemia in Patients Receiving Mechanical Ventilation: A Single-Center Cohort Study.Annals of the American Thoracic Society · 2022Article
- Modeling current practices in critical care comparative effectiveness research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Article
- Impact evaluation of a brief online training module on physician use of the Maryland, USA, Prescription Drug Monitoring Program.PloS one · 2022Article
- Too much tolerance for hyperoxemia in mechanically ventilated patients with SARS-CoV-2 pneumonia? Report from an Italian intensive care unit.Frontiers in medicine · 2022Article
- Conservative oxygen therapy in critically ill and perioperative period of patients with sepsis-associated encephalopathy.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh inspiratory oxygen concentrations are frequently administered in ventilated patients in the intensive care unit (ICU) but may induce lung injury and systemic toxicity. We compared beliefs and actual clinical practice regarding oxygen therapy in critically ill patients.
methodsIn three large teaching hospitals in the Netherlands, ICU physicians and nurses were invited to complete a questionnaire about oxygen therapy. Furthermore, arterial blood gas (ABG) analysis data and ventilator settings were retrieved to assess actual oxygen practice in the same hospitals 1 year prior to the survey.
resultsIn total, 59% of the 215 respondents believed that oxygen-induced lung injury is a concern. The majority of physicians and nurses stated that minimal acceptable oxygen saturation and partial arterial oxygen pressure (PaO2) ranges were 85% to 95% and 7 to 10 kPa (52.5 to 75 mmHg), respectively. Analysis of 107,888 ABG results with concurrent ventilator settings, derived from 5,565 patient admissions, showed a median (interquartile range (IQR)) PaO2 of 11.7 kPa (9.9 to 14.3) [87.8 mmHg], median fractions of inspired oxygen (FiO2) of 0.4 (0.4 to 0.5), and median positive end-expiratory pressure (PEEP) of 5 (5 to 8) cm H2O. Of all PaO2 values, 73% were higher than the upper limit of the commonly self-reported acceptable range, and in 58% of these cases, neither FiO2 nor PEEP levels were lowered until the next ABG sample was taken.
conclusionsMost ICU clinicians acknowledge the potential adverse effects of prolonged exposure to hyperoxia and report a low tolerance for high oxygen levels. However, in actual clinical practice, a large proportion of their ICU patients was exposed to higher arterial oxygen levels than self-reported target ranges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.