ReviewWorld journal of diabetes2014
Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus.
Review in World journal of diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Glycogenic Hepatopathy: A Case Report of a Rare Complication in Uncontrolled Diabetes.Clinical case reports · 2025Article
- Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus.BMC pediatrics · 2025Article
- Article
- Role of glucose variability on linear growth in children with type 1 diabetes.Endocrine connections · 2023Article
- Hepatic Glycogenosis: An Underdiagnosed Entity?Cureus · 2022Article
- Insulin degludec and glutamine dipeptide modify glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia.Journal of applied biomedicine · 2021Article
- Acute Hepatitis due to Hepatic Glycogenosis After Insulin Overdose and Oral Glucose Administration in an Adolescent.Journal of the Endocrine Society · 2021Article
- Clinical case conundrum: Hyperlactataemia in a case of type 1 diabetes with chronic hyperglycaemia.Diabetic medicine : a journal of the British Diabetic Association · 2021Article
- Persistent lactic acidosis in the Mauriac syndrome in type 1 diabetes mellitus.Proceedings (Baylor University. Medical Center) · 2021Article
- Image of the month: Mauriac variant: a rare complication of poorly controlled diabetes.Clinical medicine (London, England) · 2021Article
- Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review).Molecular medicine reports · 2020Review
- Elevated Lactic Acid During Ketoacidosis: Pathophysiology and Management.Journal of translational internal medicine · 2019Article
- Mauriac Syndrome: A Rare Hepatic Glycogenosis in Poorly Controlled Type 1 Diabetes.GE Portuguese journal of gastroenterology · 2019Article
- Hepatomegaly and type 1 diabetes: a clinical case of Mauriac's syndrome.Italian journal of pediatrics · 2019Article
- Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.BioMed research international · 2018Article
- Mauriac Syndrome: A Rare Complication of Type 1 Diabetes Mellitus.European journal of case reports in internal medicine · 2018Article
- Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus.Saudi medical journal · 2017Article
- Hyperketonemia and ketosis increase the risk of complications in type 1 diabetes.Free radical biology & medicine · 2016Review
- A Rare Case of Persistent Lactic Acidosis in the ICU: Glycogenic Hepatopathy and Mauriac Syndrome.Case reports in critical care · 2016Article
- Insulin overdose complicated by treatment-induced acute hepatic steatosis in a nondiabetic patient.Acute medicine & surgeryArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic glycogenosis (HG) in type 1 diabetes is a underrecognized complication. Mauriac firstly described the syndrome characterized by hepatomegaly with altered liver enzymes, growth impairment, delay puberty and Cushingoid features, during childhood. HG in adulthood is characterized by the liver disorder (with circulating aminotransferase increase) in the presence of poor glycemic control (elevation of glycated hemoglobin, HbA1c levels). The advances in the comprehension of the metabolic pathways driving to the hepatic glycogen deposition point out the role of glucose transporters and insulin mediated activations of glucokinase and glycogen synthase, with inhibition of glucose-6-phosphatase. The differential diagnosis of HG consists in the exclusion of causes of liver damage (infectious, metabolic, obstructive and autoimmune disease). The imaging study (ultrasonography and/or radiological examinations) gives information about the liver alterations (hepatomegaly), but the diagnosis needs to be confirmed by the liver biopsy. The main treatment of HG is the amelioration of glycemic control that is usually accompanied by the reversal of the liver disorder. In selected cases, more aggressive treatment options (transplantation) have been successfully reported.
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