ArticleImmunity & ageing : I & A2014
Age-related differences in polyfunctional T cell responses.
Article in Immunity & ageing : I & A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.bioRxiv : the preprint server for biology · 2026Article
- The neutrophil-to-lymphocyte ratio as a marker of immunosenescence and COVID-19 outcomes in the elderly: A narrative review.Physiological reports · 2026Review
- Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer.Frontiers in immunology · 2026Review
- Polyfunctional T peripheral helper cells are associated with the magnitude and durability of antibody responses after COVID-19.Clinical & translational immunology · 2025Article
- Anti-Inflammatory Klotho Protein Serum Concentration Correlates with Interferon Gamma Expression Related to the Cellular Activity of Both NKT-like and T Cells in the Process of Human Aging.International journal of molecular sciences · 2023Article
- Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Immunosenescence: a key player in cancer development.Journal of hematology & oncology · 2020Review
- Influence of immune aging on vaccine responses.The Journal of allergy and clinical immunology · 2020Review
- T-cell aging in end-stage renal disease: an evolving story with CMV.Medical microbiology and immunology · 2019Review
- Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E RestrictedFrontiers in immunology · 2019Article
- Differences Between Pediatric and Adult T Cell Responses toFrontiers in immunology · 2018Article
- Parameters of the Immune System and Vitamin D Levels in Old Individuals.Frontiers in immunology · 2018Article
- Influence of Aging and Environment on Presentation of Infection in Older Adults.Infectious disease clinics of North America · 2017Review
- Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis.Current neurology and neuroscience reports · 2017Review
- CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival.The Journal of infectious diseases · 2017Article
- Functional Diversity of Cytomegalovirus-Specific T Cells Is Maintained in Older People and Significantly Associated With Protein Specificity and Response Size.The Journal of infectious diseases · 2016Article
- Vδ2+ and α/ß T cells show divergent trajectories during human aging.Oncotarget · 2016Article
- Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection.Frontiers in microbiology · 2016Review
- Aβ-reactive T cell polyfunctionality response as a new biomarker for mild cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA reduced number of naïve T cells along with an accumulation of differentiated cell types in aging have been described but little is known about the polyfunctionality of the T cell responses. In this study we compared the individual and polyfunctional expression of IFN-γ, MIP-1α, TNF-α, perforin, and IL-2 by T cell subsets, including the newly described stem cell like memory T cells (TSCM), in response to stimulation with superantigen staphylococcal enterotoxin B (SEB) in older (median age 80, n = 23) versus younger (median age 27; n = 23) adults.
resultsOlder age was associated with a markedly lower frequency of CD8+ naïve T cells (11% vs. 47%; p < 0.0001) and an expansion in memory T cell subsets including central memory (p < 0.05), effector memory and effector T cells (p < 0.001 for both). There was also a decline in CD4+ naïve T cells in older subjects (33% vs. 45%; p = 0.02). There were no differences in frequencies or polyfunctional profiles of TSCM between groups. CD8+ naïve cells in the older group had increased expression of all functional parameters measured compared to the younger subjects and exhibited greater polyfunctionality (p = 0.04). CD4+ naïve T cells in the older group also showed greater polyfunctionality with a TNF-α and IL-2 predominance (p = 0.005). CD8+ effector memory and effector T cells exhibited increased polyfunctionality in the older group compared with younger (p = 0.01 and p = 0.003).
conclusionsThese data suggest that aging does not have a negative effect on polyfunctionality and therefore this is likely not a major contributor to the immunesenescence described with aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.