Evidence map›Paper›PMID 25512605›Full record

ArticleMolecular and cellular biology2015

Novel long noncoding RNAs (lncRNAs) in myogenesis: a miR-31 overlapping lncRNA transcript controls myoblast differentiation.

Monica Ballarino, Valentina Cazzella, Daniel D'Andrea, Luigi Grassi, Lavinia Bisceglie, Andrea Cipriano, Tiziana Santini, Chiara Pinnarò, Mariangela Morlando, Anna Tramontano and 1 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 94 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Monica BallarinoDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Valentina CazzellaDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Daniel D'AndreaDept. of Physics, Sapienza University of Rome, Rome, Italy.
Luigi GrassiDept. of Physics, Sapienza University of Rome, Rome, Italy.
Lavinia BisceglieDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Andrea CiprianoDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Tiziana SantiniCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Chiara PinnaròDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Mariangela MorlandoDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
Anna TramontanoDept. of Physics, Sapienza University of Rome, Rome, Italy Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
Irene BozzoniDept. of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy Institute Pasteur Fondazione Cenci-Bolognetti and IBPM, Sapienza University of Rome, Rome, Italy irene.bozzoni@uniroma1.it.
Sapienza University of Rome · ITIstituto Pasteur · ITItalian Institute of Technology · IT

Funding

Telethon GGP11149
6 · The paper itself

Abstract

Transcriptome analysis allowed the identification of new long noncoding RNAs differentially expressed during murine myoblast differentiation. These transcripts were classified on the basis of their expression under proliferating versus differentiated conditions, muscle-restricted activation, and subcellular localization. Several species displayed preferential expression in dystrophic (mdx) versus wild-type muscles, indicating their possible link with regenerative processes. One of the identified transcripts, lnc-31, even if originating from the same nuclear precursor of miR-31, is produced by a pathway mutually exclusive. We show that lnc-31 and its human homologue hsa-lnc-31 are expressed in proliferating myoblasts, where they counteract differentiation. In line with this, both species are more abundant in mdx muscles and in human Duchenne muscular dystrophy (DMD) myoblasts, than in their normal counterparts. Altogether, these data suggest a crucial role for lnc-31 in controlling the differentiation commitment of precursor myoblasts and indicate that its function is maintained in evolution despite the poor sequence conservation with the human counterpart.

Indexed as

AnimalsBiological EvolutionCell DifferentiationCell ProliferationGene Expression ProfilingGene Expression RegulationHumansMiceMice, TransgenicMicroRNAsMuscle DevelopmentMuscle, SmoothMuscle, StriatedMuscular Dystrophy, DuchenneMyoblastsRNA, Long NoncodingMicroRNAsMIRN31 microRNA, humanMirn31 microRNA, mouseRNA, Long NoncodingRNA Precursors

Identifiers

PMID25512605
PMCPMC4301723
OpenAlexW1907041640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.