ArticleGenes & development2014
The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- LSD1 maintains oocyte quality by epigenetically repressing CAMK2β to control granulosa cell-oocyte communication.Journal of translational medicine · 2026Article
- Article
- SPR-1/CoREST facilitates the maternal epigenetic reprogramming of the histone demethylase SPR-5/LSD1.Genetics · 2023Article
- Illuminati: a form of gene expression plasticity in Drosophila neural stem cells.Development (Cambridge, England) · 2022Article
- A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis.BMC biology · 2022Article
- Kinesin-directed secretion of basement membrane proteins to a subdomain of the basolateral surface in Drosophila epithelial cells.Current biology : CB · 2022Article
- Histone lysine-specific demethylase 1 regulates the proliferation of hemocytes in the oysterFrontiers in immunology · 2022Article
- Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells.Stem cell research & therapy · 2020Article
- LSD1 contributes to programmed oocyte death by regulating the transcription of autophagy adaptor SQSTM1/p62.Aging cell · 2020Article
- A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.Nucleic acids research · 2020Article
- Distinct CoREST complexes act in a cell-type-specific manner.Nucleic acids research · 2019Article
- Downregulation of homeodomain protein Cut is essential forDevelopment (Cambridge, England) · 2019Article
- BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis.American journal of cancer research · 2018Article
- Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation.G3 (Bethesda, Md.) · 2017Article
- Notch signalling in context.Nature reviews. Molecular cell biology · 2016Review
- The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop.Molecular and cellular biology · 2015Article
- The expanding implications of polyploidy.The Journal of cell biology · 2015Review
- Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.PloS one · 2015Article
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2 authors.
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Abstract
Progenitors are early lineage cells that proliferate before the onset of terminal differentiation. Although widespread, the epigenetic mechanisms that control the progenitor state and the onset of differentiation remain elusive. By studying Drosophila ovarian follicle cell progenitors, we identified lysine-specific demethylase 1 (lsd1) and CoRest as differentiation regulators using a GAL4∷GFP variegation assay. The follicle cell progenitors in lsd1 or CoRest heterozygotes prematurely lose epigenetic plasticity, undergo the Notch-dependent mitotic-endocycle transition, and stop dividing before a normal number of follicle cells can be produced. Simultaneously reducing the dosage of the histone H3K4 methyltransferase Trithorax reverses these effects, suggesting that an Lsd1/CoRest complex times progenitor differentiation by controlling the stability of H3K4 methylation levels. Individual cells or small clones initially respond to Notch; hence, a critical level of epigenetic stabilization is acquired cell-autonomously and initiates differentiation by making progenitors responsive to pre-existing external signals.
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