ArticleProceedings of the National Academy of Sciences of the United States of America2014
Auxin depletion from leaf primordia contributes to organ patterning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Overview of molecular mechanisms of plant leaf development: a systematic review.Frontiers in plant science · 2023Pooled it
- Regeneration from seeds with physical defects: Contrasts in survival strategies in recalcitrant and orthodox seeds.Plant diversity · 2026Review
- SlBL4 is involved in leaf polarity development in tomato.Frontiers in plant science · 2026Article
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Apocarotenoid signaling regulates meristem activity and shapes shoot and root lateral organ formation in Arabidopsis.Plant physiology · 2025Article
- Stem Cell Factors BAM1 and WOX1 Suppressing Longitudinal Cell Division of Margin Cells Evoked by Low-Concentration Auxin in Young Cotyledon of Arabidopsis.International journal of molecular sciences · 2025Article
- Establishment and maintenance of embryogenic cell fate during microspore embryogenesis.The Plant journal : for cell and molecular biology · 2025Article
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- 'Organ'ising Floral Organ Development.Plants (Basel, Switzerland) · 2024Review
- Transcriptomic analyses to summarize gene expression patterns that occur during leaf initiation of Chinese cabbage.Horticulture research · 2024Article
- Advancements in Rice Leaf Development Research.Plants (Basel, Switzerland) · 2024Review
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
- Diversification of ranunculaceous petals in shape supports a generalized model for plant lateral organ morphogenesis and evolution.Science advances · 2023Article
- Polar auxin transport modulates early leaf flattening.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- On the trail of auxin: Reporters and sensors.The Plant cell · 2022Review
- Molecular mechanisms underlying leaf development, morphological diversification, and beyond.The Plant cell · 2022Review
- CRISPR-Cas9-mediated mutagenesis of the SlSRM1-like gene leads to abnormal leaf development in tomatoes.BMC plant biology · 2022Article
- Postembryonic Organogenesis in Plants: Experimental Induction of New Shoot and Root Organs.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Adaxial/Abaxial Patterning of Auxin and Auxin Gene in Leaf Veins Functions in Leafy Head Formation of Chinese Cabbage.Frontiers in plant science · 2022Article
- Manganese toxicity disrupts indole acetic acid homeostasis and suppresses the COScientific reports · 2021Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Stem cells are responsible for organogenesis, but it is largely unknown whether and how information from stem cells acts to direct organ patterning after organ primordia are formed. It has long been proposed that the stem cells at the plant shoot apex produce a signal, which promotes leaf adaxial-abaxial (dorsoventral) patterning. Here we show the existence of a transient low auxin zone in the adaxial domain of early leaf primordia. We also demonstrate that this adaxial low auxin domain contributes to leaf adaxial-abaxial patterning. The auxin signal is mediated by the auxin-responsive transcription factor MONOPTEROS (MP), whose constitutive activation in the adaxial domain promotes abaxial cell fate. Furthermore, we show that auxin flow from emerging leaf primordia to the shoot apical meristem establishes the low auxin zone, and that this auxin flow contributes to leaf polarity. Our results provide an explanation for the hypothetical meristem-derived leaf polarity signal. Opposite to the original proposal, instead of a signal derived from the meristem, we show that a signaling molecule is departing from the primordium to the meristem to promote robustness in leaf patterning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.