Evidence map›Paper›PMID 25512402›Full record

ArticleAntimicrobial agents and chemotherapy2015

Multilaboratory testing of antifungal drug combinations against Candida species and Aspergillus fumigatus: utility of 100 percent inhibition as the endpoint.

Ping Ren, Ming Luo, Shao Lin, Mahmoud A Ghannoum, Nancy Isham, Dan J Diekema, Michael A Pfaller, Shawn Messer, Shawn R Lockhart, Naureen Iqbal and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Article
  3. Article
  4. Antimicrobial agents and chemotherapy · 2020
    Article
  5. Article
  6. Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ping RenMycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA ping.ren@health.ny.gov.
Ming LuoBureau of Environmental & Occupational Epidemiology, New York State Department of Health, Albany, New York, USA.
Shao LinBureau of Environmental & Occupational Epidemiology, New York State Department of Health, Albany, New York, USA.
Mahmoud A GhannoumCenter for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Nancy IshamCenter for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
Dan J DiekemaMedical Microbiology Division, Department of Pathology, University of Iowa, Iowa City, Iowa, USA.
Michael A PfallerMedical Microbiology Division, Department of Pathology, University of Iowa, Iowa City, Iowa, USA.
Shawn MesserMedical Microbiology Division, Department of Pathology, University of Iowa, Iowa City, Iowa, USA.
Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Naureen IqbalMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Vishnu ChaturvediMycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Four laboratories tested three isolates of Candida species and two isolates of Aspergillus fumigatus using 96-well plates containing combinations of amphotericin B, anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole, and voriconazole. The majority of summation fractional inhibitory concentration indices (ΣFICI) based on the Lowe additivity formula suggested indifferent drug interactions (ΣFICI > 0.5 and ≤4.0) and no instance of drug antagonism (ΣFICI > 4.0). The intra- and interlaboratory agreement rates were superior when MIC100 readings were used as endpoints (at a 99% confidence interval [CI]).

Indexed as

Antifungal AgentsAspergillus fumigatusCandidaDrug CombinationsMicrobial Sensitivity TestsAntifungal AgentsDrug Combinations

Identifiers

PMID25512402
PMCPMC4325810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.