ArticleThe Journal of biological chemistry2015
The B-type channel is a major route for iron entry into the ferroxidase center and central cavity of bacterioferritin.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- The assembly rules guiding hetero-oligomeric bacterioferritin organization and their evolutionary signature.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Iron-Sulfur Cluster of Bacterioferritin-Associated Ferredoxin (Bfd): a "Biological Fuse" that Prevents Oxidative Damage to Cells?Angewandte Chemie (International ed. in English) · 2025Article
- Mobilization of iron stored in bacterioferritin, a new target for perturbing iron homeostasis and developing antibacterial and antibiofilm molecules.Journal of inorganic biochemistry · 2023Review
- Morphological difference of Escherichia coli non-heme ferritin iron cores reconstituted in the presence and absence of inorganic phosphate.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
- Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology.ACS bio & med chem Au · 2022Review
- Key carboxylate residues for iron transit through the prokaryotic ferritinMicrobiology (Reading, England) · 2021Article
- Bacterial iron detoxification at the molecular level.The Journal of biological chemistry · 2020Review
- Serendipitous crystallization and structure determination of bacterioferritin from Achromobacter.Acta crystallographica. Section F, Structural biology communications · 2018Article
- Bacterioferritin: Structure, Dynamics, and Protein-Protein Interactions at Play in Iron Storage and Mobilization.Accounts of chemical research · 2017Article
- Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution.Scientific reports · 2016Article
- Ferritins: furnishing proteins with iron.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Review
- Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2015Article
- Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.Angewandte Chemie (International ed. in English) · 2015Article
- A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage.The Journal of biological chemistry · 2015Article
- Self-assembly is prerequisite for catalysis of Fe(II) oxidation by catalytically active subunits of ferritin.The Journal of biological chemistry · 2015Article
- Fe(2+) substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacterioferritin is a bacterial iron storage and detoxification protein that is capable of forming a ferric oxyhydroxide mineral core within its central cavity. To do this, iron must traverse the bacterioferritin protein shell, which is expected to occur through one or more of the channels through the shell identified by structural studies. The size and negative electrostatic potential of the 24 B-type channels suggest that they could provide a route for iron into bacterioferritin. Residues at the B-type channel (Asn-34, Glu-66, Asp-132, and Asp-139) of E. coli bacterioferritin were substituted to determine if they are important for iron core formation. A significant decrease in the rates of initial oxidation of Fe(II) at the ferroxidase center and subsequent iron mineralization was observed for the D132F variant. The crystal structure of this variant shows that substitution of residue 132 with phenylalanine caused a steric blockage of the B-type channel and no other material structural perturbation. We conclude that the B-type channel is a major route for iron entry into both the ferroxidase center and the iron storage cavity of bacterioferritin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.