ArticleDevelopmental biology2015
Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Magnolol enhances yak oocyte maturation and blastocyst quality by improving lipid metabolism and redox homeostasis through a PPARγ-dependent mechanism.Journal of animal science and biotechnology · 2026Article
- Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.Nature structural & molecular biology · 2024Article
- The Price of Human Evolution: Cancer-Testis Antigens, the Decline in Male Fertility and the Increase in Cancer.International journal of molecular sciences · 2023Review
- Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development of aneuploid mouse embryos through a Trp53-dependent mechanism.Journal of assisted reproduction and genetics · 2023Article
- Transcription of MERVL retrotransposons is required for preimplantation embryo development.Nature genetics · 2023Article
- 12-Oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells.Animal bioscience · 2023Article
- Maternal effect genes as risk factors for congenital heart defects.HGG advances · 2022Article
- Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation.Frontiers in endocrinology · 2022Article
- Trophoblast lineage specification in the mammalian preimplantation embryo.Reproductive medicine and biology · 2020Review
- Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast.Molecular human reproduction · 2020Article
- Maternal factors regulating preimplantation development in mice.Current topics in developmental biology · 2020Review
- MicroRNA-451 is downregulated in the follicular fluid of women with endometriosis and influences mouse and human embryonic potential.Reproductive biology and endocrinology : RB&E · 2019Article
- FGFR1 regulates trophectoderm development and facilitates blastocyst implantation.Developmental biology · 2019Article
- Review
- Role of yes-associated protein 1, angiomotin, and mitogen-activated kinase kinase 1/2 in development of the bovine blastocyst.Biology of reproduction · 2018Article
- Single-cell gene expression of the bovine blastocyst.Reproduction (Cambridge, England) · 2017Article
- Evidence of Oocyte Polarity in Bovine; Implications for Intracytoplasmic Sperm Injection and Somatic Cell Nuclear Transfer.Cell journal · 2017Article
- Causes and evolutionary consequences of primordial germ-cell specification mode in metazoans.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?Stem cell reviews and reports · 2016Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The first lineage segregation in the mouse embryo generates the inner cell mass (ICM), which gives rise to the pluripotent epiblast and therefore the future embryo, and the trophectoderm (TE), which will build the placenta. The TE lineage depends on the transcription factor Cdx2. However, when Cdx2 first starts to act remains unclear. Embryos with zygotic deletion of Cdx2 develop normally until the late blastocyst stage leading to the conclusion that Cdx2 is important for the maintenance but not specification of the TE. In contrast, down-regulation of Cdx2 transcripts from the early embryo stage results in defects in TE specification before the blastocyst stage. Here, to unambiguously address at which developmental stage Cdx2 becomes first required, we genetically deleted Cdx2 from the oocyte stage using a Zp3-Cre/loxP strategy. Careful assessment of a large cohort of Cdx2 maternal-zygotic null embryos, all individually filmed, examined and genotyped, reveals an earlier lethal phenotype than observed in Cdx2 zygotic null embryos that develop until the late blastocyst stage. The developmental failure of Cdx2 maternal-zygotic null embryos is associated with cell death and failure of TE specification, starting at the morula stage. These results indicate that Cdx2 is important for the correct specification of TE from the morula stage onwards and that both maternal and zygotic pools of Cdx2 are required for correct pre-implantation embryogenesis.
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