ReviewClinica chimica acta; international journal of clinical chemistry2015
Urinary C-type natriuretic peptide: an emerging biomarker for heart failure and renal remodeling.
Review in Clinica chimica acta; international journal of clinical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The effect of natriuretic C-type peptide and its change over time on mortality in patients on haemodialysis or haemodiafiltration.Clinical kidney journal · 2021Article
- Deciphering key genes in cardio-renal syndrome using network analysis.Bioinformation · 2021Article
- Galectin-3: A Potential Prognostic and Diagnostic Marker for Heart Disease and Detection of Early Stage Pathology.Biomolecules · 2020Review
- CRRL269.Circulation research · 2019Article
- C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.Journal of molecular and cellular cardiology · 2019Article
- N-Terminal pro C-Type Natriuretic Peptide (NTproCNP) and myocardial function in ageing.PloS one · 2018Article
- Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes.PloS one · 2018Article
- Novel Biomarkers for the Risk Stratification of Heart Failure with Preserved Ejection Fraction.Current heart failure reports · 2017Review
- Resetting the neurohormonal balance in heart failure (HF): the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF.Heart failure reviews · 2017Review
- Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen.Peptides · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The public health and economic burden of heart failure (HF) is staggering and the need for relevant pathophysiologic and clinical biomarkers to advance the field and improve HF therapy remains high. Renal dysfunction is common among HF patients and is associated with increased HF hospitalization and mortality. It is widely recognized that mechanisms contributing to HF pathogenesis include a complex bidirectional interaction between the kidney and heart, encompassed by the term cardiorenal syndrome (CRS). Among a new wave of urinary biomarkers germane to CRS, C-type natriuretic peptide (CNP) has emerged as an innovative biomarker of renal structural and functional impairment in HF and chronic renal disease states. CNP is a hormone, synthesized in the kidney, and is an important regulator of cell proliferation and organ fibrosis. Hypoxia, cytokines and fibrotic growth factors, which are inherent to both cardiac and renal remodeling processes, are among the recognized stimuli for CNP production and release. In this review we aim to highlight current knowledge regarding the biology and pathophysiological correlates of urinary CNP, and its potential clinical utility as a diagnostic and prognostic biomarker in HF and renal disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.