ArticleBMC veterinary research2014
Parasite distribution and associated immune response during the acute phase of Toxoplasma gondii infection in sheep.
Article in BMC veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- BKI-1748 confers a high level of protection against ovine congenital toxoplasmosis when administered after IgM seroconversion.Frontiers in cellular and infection microbiology · 2026Article
- The Acute Immune Response in Sheep Following Immunization withVeterinary sciences · 2025Article
- Early dynamics of Toxoplasma gondii infection in sheep inoculated at mid-gestation with archetypal type II oocysts.Veterinary research · 2025Article
- Evaluation of the Protective Efficacy of Different Doses of aAnimals : an open access journal from MDPI · 2024Article
- Article
- Recombinant AMA1 Virus-like Particle Antigen for Serodiagnosis ofBiomedicines · 2022Article
- Advances in vaccine development and the immune response against toxoplasmosis in sheep and goats.Frontiers in veterinary science · 2022Review
- Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020Review
- Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep.Frontiers in immunology · 2020Article
- Early Kinetics of Intestinal Infection and Immune Responses to TwoFrontiers in cellular and infection microbiology · 2020Article
- Peripheral and placental immune responses in sheep after experimental infection with Toxoplasma gondii at the three terms of gestation.Veterinary research · 2019Article
- QuilA-AdjuvantedFrontiers in immunology · 2019Article
- Dextran sulfate inhibits acute Toxoplama gondii infection in pigs.Parasites & vectors · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn many countries, Toxoplasma gondii (T. gondii) is a major cause of reproductive disorders and abortions in the sheep industry, and therefore responsible for important financial and economic losses. In addition, undercooked infected lamb is an important risk factor for human toxoplasmosis. In the present study, the initial phase of the infection was investigated: the parasite's entry site, the subsequent distribution of the parasite and the host-immune response.
resultsParasite DNA was already detected in the cranial small intestinal mucosa the first days after oral infection with T. gondii tissue cysts. Simultaneously, high IFN-gamma and IL-12 responses were induced mainly in the mesenteric lymph nodes. The emergence of IgG1 (at 8dpi), and IgG2 (at 11 dpi) was accompanied by a decrease or even disappearance of the IFN-gamma and IL-12 response in the Peyers' patches (PP), PBMC's and popliteal LN's. Meanwhile the parasite DNA could be recovered from most mucosal and systemic tissues to become undetectable in the small intestine, popliteal LN, PBMC and spleen 3 weeks pi.
conclusionsOur results indicate that parasites enter the cranial small intestine the first days after infection and that after an increase the first two weeks after infection, the parasite DNA levels in the intestine drop below the detection limit three weeks after infection. This coincides with an increase in parastic-specific serum IgG1 and IgG2 and a decrease of the antigen-specific IFN-gamma response in PP, PBMC and popliteal LN. We suggest a role for IFN-gamma and IL-12 in controlling the infection.
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