Evidence map›Paper›PMID 25511548›Full record

ArticleNeuroscience letters2015

Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.

Aaron M Gusdon, Fang Fang, Jing Chen, Clayton E Mathews, Wang Li, Charleen T Chu, Jian-Qing Ding, Sheng-di Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Aaron M GusdonDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China; Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA.
Fang FangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China.
Jing ChenDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
Clayton E MathewsDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610-0275, USA.
Wang LiClinical and Translational Science Institute (CTSI), University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA.
Charleen T ChuDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Jian-Qing DingDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China.
Sheng-di ChenDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, No. 197, Rui Jin Er Road, Shanghai 200025, China. Electronic address: chen_sd@medmail.com.cn.
Shanghai Jiao Tong University · CNUniversity of Florida · USUniversity of Pittsburgh · USCornell University · USRuijin Hospital · CN

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Regulation of Autophagy & Mitochondrial Recycling in Neuronal Cell Death- SupplementR01AG026389 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CHARLEEN T · 2007 to 2024
$6.0M
mt-Nd2 and Resistance to Autoimmune DiabetesR01DK074656 · NIDDK · UNIVERSITY OF FLORIDA · PI MATHEWS, CLAYTON E · 2006 to 2015
$2.8M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1TR000005NIA NIH HHS 5R01AG026389-07NIA NIH HHS R01 AG026389NIDDK NIH HHS R01 DK074656NIDDK NIH HHS R01DK074656
6 · The paper itself

Abstract

Mitochondria play an important role in the etiology of Parkinson's disease (PD). While mutations in the mitochondrial DNA (mtDNA) have been shown to accumulate in PD, no specific mtDNA polymorphisms have been associated with susceptibility or resistance to PD. A cytosine to adenine transversion at base pair 5178 in the mtDNA has been associated with increased longevity and resistance against a number of age related disorders and has been shown to decrease mitochondrial reactive oxygen species (ROS) production. We sought to determine whether 5178A is associated with resistance against PD in a Han Chinese population. To assess its association with PD, we genotyped 484 idiopathic PD patients and 710 control individuals for 5178C/A. Genotyping was performed using restriction fragment length polymorphism (RFLP) analysis. There was no significant association between 5178A and PD (P=0.308) when analyzing the entire population. However, sub-group analysis revealed that in males the frequency of 5178A was significantly lower in PD patients (27.7% in controls vs 20.0% in PD patients, P=0.027). Stratification of the population by age showed that this trend held across age groups but only reached statistical significance in males aged 60-70 (29.1% in controls vs 14.05 in PD patients, P=0.011). In conclusion, we demonstrated that the frequency of 5178A was significantly decreased in male PD patients in a Han Chinese population. This polymorphism may be associated with resistance against the development of PD when in combination with loci on the Y chromosome.

Indexed as

AgedAge FactorsAsian PeopleCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedMitochondriaNADH DehydrogenaseParkinson DiseasePolymorphism, GeneticSex FactorsNADH DehydrogenaseNADH dehydrogenase subunit 2, human5178AComplex IMitochondrial DNAmt-ND2NADH dehydrogenaseParkinson’s disease

Identifiers

PMID25511548
PMCPMC4934122
OpenAlexW2007645079

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.