Evidence map›Paper›PMID 25511385›Full record

ArticleClinical oral investigations2015

Stage-related treatment concept of medication-related osteonecrosis of the jaw-a case series.

Petra Rugani, Stephan Acham, Barbara Kirnbauer, Astrid Truschnegg, Barbara Obermayer-Pietsch, Norbert Jakse

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Review
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  8. Review
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  12. Review
  13. Medication-related osteonecrosis of the jaw: Clinical and practical guidelines.Journal of International Society of Preventive & Community Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petra RuganiDepartment of Oral Surgery and Radiology, Medical University of Graz, Graz, Austria, petra.rugani@medunigraz.at.
Stephan Acham
Barbara Kirnbauer
Astrid Truschnegg
Barbara Obermayer-Pietsch
Norbert Jakse

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThere is no general consensus for treatment of medication-related osteonecrosis of the jaw (MRONJ). A stage-related approach that primarily aims to minimize morbidity and preserve function was prospectively evaluated. PATIENTS AND

methodsTreatment goals are stable mucosal closure and absence of clinical symptoms. Patients were enrolled between March 2010 and October 2011. MRONJ lesions were treated either by conservative means or surgically by debridement or resective surgery.

resultsIn total, 38 patients were treated. Six patients were healed by undergoing conservative measures; nine were treated palliatively. Four patients dropped out after surgery in the recall phase. In 17 of 19 patients (89.5%) surgical treatment was successful. After a 1-year observation period, the success rate was 92% (23 of 25), including all patients treated as per protocol.

conclusionIn stage-related treatment, conservative means or surgical debridement can be successful at early stages. Extensive resection is solely indicated in cases of extended necrosis. CLINICAL RELEVANCE: The number of patients with MRONJ is steadily increasing. Guidelines to deal with this condition are helpful for both clinicians and dental practitioners.

Indexed as

AdultAgedAged, 80 and overAustriaBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsConservative TreatmentDebridementFemaleHumansMaleMiddle AgedOral Surgical ProceduresPalliative CareProspective StudiesTreatment OutcomeBone Density Conservation Agents

Identifiers

PMID25511385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.