ArticleNature communications2014
An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Transcriptional responses in feeder time-trained foragers suggest diverse interactions between the circadian clock and mushroom bodies in honey bees.Scientific reports · 2025Article
- Clock-dependent chromatin accessibility rhythms regulate circadian transcription.PLoS genetics · 2024Article
- Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants.Cell · 2023Article
- Starvation selection reduces and delays larval ecdysone production and signaling.The Journal of experimental biology · 2023Article
- Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock.PLoS genetics · 2023Article
- Coregulators Reside withinInternational journal of molecular sciences · 2023Article
- Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.Scientific reports · 2023Article
- Article
- Cloning and functional analysis of the molting gene CYP302A1 of Daphnia sinensis.Frontiers in zoology · 2023Article
- Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.PloS one · 2023Article
- Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity.Cancer biology & therapy · 2022Review
- Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.Current biology : CB · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Role of Bmal1 in mediating the cholinergic system to regulate the behavioral rhythm of nocturnal marine molluscs.Computational and structural biotechnology journal · 2022Article
- The circadian clock gatesProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of genes and gene expression associated with dispersal capacity in the mountain pine beetle,PeerJ · 2021Article
- Bilberry (Antioxidants (Basel, Switzerland) · 2020Article
- Transcriptomics supports local sensory regulation in the antenna of the kissing-bug Rhodnius prolixus.BMC genomics · 2020Article
- Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020Review
- Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.Molecular psychiatry · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
Little is known about molecular links between circadian clocks and steroid hormone signalling, although both are important for normal physiology. Here we report a circadian function for a nuclear receptor, ecdysone-induced protein 75 (Eip75/E75), which we identified through a gain-of-function screen for circadian genes in Drosophila melanogaster. Overexpression or knockdown of E75 in clock neurons disrupts rest:activity rhythms and dampens molecular oscillations. E75 represses expression of the gene encoding the transcriptional activator, CLOCK (CLK), and may also affect circadian output. PER inhibits the activity of E75 on the Clk promoter, thereby providing a mechanism for a previously proposed de-repressor effect of PER on Clk transcription. The ecdysone receptor is also expressed in central clock cells and manipulations of its expression produce effects similar to those of E75 on circadian rhythms. We find that E75 protects rhythms under stressful conditions, suggesting a function for steroid signalling in the maintenance of circadian rhythms in Drosophila.
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