ArticleBMC genomics2014
Targeted resequencing of GWAS loci reveals novel genetic variants for milk production traits.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- Genome-Wide Association Studies of Milk Composition Traits in Holstein Cattle Raised in Tropical and Subtropical Conditions.Animals : an open access journal from MDPI · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats.Journal of animal science and biotechnology · 2026Article
- Signature of Selection Analysis Reveals Candidate Genes Related to Climate Adaptation and Production Traits in Lao Native Goats.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations.Science China. Life sciences · 2025Review
- Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept.HLA · 2025Article
- HSF1 and CPSF1 affect milk fat and protein synthesis by regulating the AKT/mTOR signaling pathway.Journal of animal science · 2025Article
- Single nucleotide polymorphisms ofAnimal biotechnology · 2024Article
- DNA methylation of GDF-9 and GHR genes as epigenetic regulator of milk production in Egyptian Zaraibi goat.Genes & genomics · 2024Article
- Genome-Wide Association Study of Lactation Traits in Chinese Holstein Cows in Southern China.Animals : an open access journal from MDPI · 2023Article
- Article
- Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study.BMC genomics · 2023Article
- Genome-wide diversity and admixture of five indigenous cattle populations from the Tigray region of northern Ethiopia.Frontiers in genetics · 2023Article
- The Candidate Chromosomal Regions Responsible for Milk Yield of Cow: A GWAS Meta-Analysis.Animals : an open access journal from MDPI · 2022Article
- Investigating the Effect of Imputed Structural Variants from Whole-Genome Sequence on Genome-Wide Association and Genomic Prediction in Dairy Cattle.Animals : an open access journal from MDPI · 2021Article
- Development of GBTS and KASP Panels for Genetic Diversity, Population Structure, and Fingerprinting of a Large Collection of Broccoli (Frontiers in plant science · 2021Article
- Article
- Target sequencing reveals genetic diversity, population structure, core-SNP markers, and fruit shape-associated loci in pepper varieties.BMC plant biology · 2019Article
- A targeted genotyping approach to enhance the identification of variants for lactation persistency in dairy cows.Journal of animal science · 2019Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenome wide association study (GWAS) has been proven to be a powerful tool for detecting genomic variants associated with complex traits. However, the specific genes and causal variants underlying these traits remain unclear.
resultsHere, we used target-enrichment strategy coupled with next generation sequencing technique to study target regions which were found to be associated with milk production traits in dairy cattle in our previous GWAS. Among the large amount of novel variants detected by targeted resequencing, we selected 200 SNPs for further association study in a population consisting of 2634 cows. Sixty six SNPs distributed in 53 genes were identified to be associated significantly with on milk production traits. Of the 53 genes, 26 were consistent with our previous GWAS results. We further chose 20 significant genes to analyze their mRNA expression in different tissues of lactating cows, of which 15 were specificly highly expressed in mammary gland.
conclusionsOur study illustrates the potential for identifying causal mutations for milk production traits using target-enrichment resequencing and extends the results of GWAS by discovering new and potentially functional mutations.
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