Evidence map›Paper›PMID 25510937›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

Hippocampal cannabinoid transmission modulates dopamine neuron activity: impact on rewarding memory formation and social interaction.

Michael Loureiro, Justine Renard, Jordan Zunder, Steven R Laviolette

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 66 citations in OpenAlex.

  1. A randomised controlled trial of vaporised ΔEuropean archives of psychiatry and clinical neuroscience · 2019
    Trial
  2. Article
  3. The effect of traumatic brain injury on learning and memory: A synaptic focus.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  4. Article
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  6. Article
  7. Review
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  12. Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Article
  19. Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  20. Cannabinoid disruption of learning mechanisms involved in reward processing.Learning & memory (Cold Spring Harbor, N.Y.) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael LoureiroDepartment of Anatomy and Cell Biology, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Justine RenardDepartment of Anatomy and Cell Biology, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Jordan ZunderDepartment of Anatomy and Cell Biology, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Steven R Laviolette1] Department of Anatomy and Cell Biology, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada [2] Department of Psychiatry, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada [3] Department of Psychology, The Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.
Western University · CA

Funding

Canadian Institutes of Health Research MOP 246144
6 · The paper itself

Abstract

Disturbances in cannabinoid type 1 receptor (CB1R) signaling have been linked to emotional and cognitive deficits characterizing neuropsychiatric disorders, including schizophrenia. Thus, there is growing interest in characterizing the relationship between cannabinoid transmission, emotional processing, and dopamine (DA)-dependent behavioral deficits. The CB1R is highly expressed in the mammalian nervous system, particularly in the hippocampus. Activation of the ventral hippocampal subregion (vHipp) is known to increase both the activity of DAergic neurons located in the ventral tegmental area (VTA) and DA levels in reward-related brain regions, particularly the nucleus accumbens (NAc). However, the possible functional relationship between hippocampal CB1R transmission and VTA DA neuronal activity is not currently understood. In this study, using in vivo neuronal recordings in rats, we demonstrate that activation of CB1R in the vHipp strongly increases VTA DA neuronal firing and bursting activity, while simultaneously decreasing the activity of VTA non-DA neurons. Furthermore, using a conditioned place preference procedure and a social interaction test, we report that intra-vHipp CB1R activation potentiates the reward salience of normally sub-threshold conditioning doses of opiates and induces deficits in natural sociability and social recognition behaviors. Finally, these behavioral effects were prevented by directly blocking NAc DAergic transmission. Collectively, these findings identify hippocampal CB1R transmission as a critical modulator of the mesolimbic DA pathway and in the processing of reward and social-related behavioral phenomena.

Indexed as

Interpersonal RelationsRewardAction PotentialsAnimalsDopaminergic NeuronsHippocampusMaleMemoryNucleus AccumbensRats, Sprague-DawleyReceptor, Cannabinoid, CB1Receptors, DopamineSpatial BehaviorVentral Tegmental AreaCnr1 protein, ratReceptor, Cannabinoid, CB1Receptors, Dopamine

Identifiers

PMID25510937
PMCPMC4397402
OpenAlexW2062367858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.