ArticleYonsei medical journal2015
A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women.
Article in Yonsei medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Different Polymorphisms of the Renin-Angiotensin-Aldosterone System Genes are Associated with Poorer Blood Pressure Control in Hypertensive Older Adults.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Article
- Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.Endocrine reviews · 2019Review
- Haplotype-based association of renin gene polymorphisms with essential hypertension in Han population of northern china.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
purposeThe aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. MATERIALS AND
methodsTo outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects.
resultsLogistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069-2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant.
conclusionWe suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.
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