ArticleYonsei medical journal2015
Clinical implications of microsatellite instability in T1 colorectal cancer.
Article in Yonsei medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Rate of dissemination and prognosis in early and advanced stage colorectal cancer based on microsatellite instability status: systematic review and meta-analysis.International journal of colorectal disease · 2021Pooled it
- Prognostic significance of bone marrow and spleenScientific reports · 2021Trial
- Review
- Comment on "How Does Omitting Additional Surgery After Local Excision Affect the Prognostic Outcome of Patients With High-Risk T1 Colorectal Cancer?"Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Article
- Prediction of Microsatellite Instability in Colorectal Cancer Using a Machine Learning Model Based on PET/CT Radiomics.Yonsei medical journal · 2023Article
- Molecular Oncology in Management of Colorectal Cancer.Indian journal of surgical oncology · 2021Article
- Correlations between microsatellite instability and the biological behaviour of tumours.Journal of cancer research and clinical oncology · 2019Review
- Clinical significance of tumor-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio in patients with stage III colon cancer who underwent surgery followed by FOLFOX chemotherapy.Scientific reports · 2019Article
- Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.Cancer communications (London, England) · 2019Review
- Pathological risk factors for lymph node metastasis in patients with submucosal invasive colorectal carcinoma.Cancer management and research · 2019Article
- Prognostic significance of microsatellite instability‑associated pathways and genes in gastric cancer.International journal of molecular medicine · 2018Article
- The prognostic implications of primary tumor location on recurrence in early-stage colorectal cancer with no associated risk factors.International journal of colorectal disease · 2018Article
- Strategy to targeting the immune resistance and novel therapy in colorectal cancer.Cancer medicine · 2018Review
- Prognosis of stage III colorectal carcinomas with FOLFOX adjuvant chemotherapy can be predicted by molecular subtype.Oncotarget · 2017Article
- Patient gender as a factor associated with lymph node metastasis in T1 colorectal cancer: A systematic review and meta-analysis.Molecular and clinical oncology · 2017Article
- Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population.OncoTargets and therapy · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe estimation of regional lymph node metastasis (LNM) risk in T1 colorectal cancer is based on histologic examination and imaging of the primary tumor. High-frequency microsatellite instability (MSI-H) is likely to decrease the possibility of metastasis to either regional lymph nodes or distant organs in colorectal cancers. This study evaluated the clinical implications of MSI in T1 colorectal cancer with emphasis on the usefulness of MSI as a predictive factor for regional LNM. MATERIALS AND
methodsA total of 133 patients who underwent radical resection for T1 colorectal cancer were included. Genomic DNA was extracted from normal and tumor tissues and amplified by polymerase chain reaction (PCR). Five microsatellite markers, BAT-25, BAT-26, D2S123, D5S346, and D17S250, were used. MSI and clinicopathological parameters were evaluated as potential predictors of LNM using univariate and multivariate analyses.
resultsAmong 133 T1 colorectal cancer patients, MSI-H, low-frequency microsatellite instability (MSI-L), and microsatellite stable (MSS) colorectal cancers accounted for 7.5%, 6%, and 86.5%, respectively. MSI-H tumors showed a female predominance, a proximal location and more retrieved lymph nodes. Twenty-two patients (16.5%) had regional LNM. Lymphovascular invasion and depth of invasion were significantly associated with LNM. There was no LNM in 10 MSI-H patients; however, MSI status was not significantly correlated with LNM. Disease-free survival did not differ between patients with MSI-H and those with MSI-L/MSS.
conclusionMSI status could serve as a negative predictive factor in estimating LNM in T1 colorectal cancer, given that LNM was not detected in MSI-H patients. However, validation of our result in a different cohort is necessary.
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