Evidence map›Paper›PMID 25510582›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Adult bone strength of children from single-parent families: the Midlife in the United States Study.

C J Crandall, A S Karlamangla, S S Merkin, N Binkley, D Carr, G A Greendale, T E Seeman

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

C J CrandallDepartment of Medicine, David Geffen School of Medicine, Los Angeles, University of California, Los Angeles, UCLA Medicine/GIM, 911 Broxton Ave., 1st Floor, Los Angeles, CA, 90024, USA, ccrandall@mednet.ucla.edu.
A S Karlamangla
S S Merkin
N Binkley
D Carr
G A Greendale
T E Seeman

Funding

STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Lifespan Psychosocial Profiles and Biological Pathways to Bone StrengthR01AG033067 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRANDALL, CAROLYN JANET, KARLAMANGLA, ARUN S · 2009 to 2012
$1.4M
Histories of Social Engagement and Cognitive FunctioningR01AG032271 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEEMAN, TERESA E · 2009 to 2010
$999k
NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR000865NIA NIH HHS 1R01AG033067NIA NIH HHS P01 AG020166NIA NIH HHS P01-AG-020166NIA NIH HHS R01 AG032271NIA NIH HHS R01-AG-032271NIA NIH HHS R01 AG033067
6 · The paper itself

Abstract

unlabelledBone health may be negatively impacted by childhood socio-environmental circumstances. We examined the independent associations of single-parent childhood and parental death or divorce in childhood with adult bone strength indices. Longer exposure to a single-parent household in childhood was associated with lower bone strength in adulthood.

introductionBecause peak bone mass is acquired during childhood, bone health may be negatively impacted by childhood socio-environmental disadvantage. The goal of this study was to determine whether being raised in a single-parent household is associated with lower bone strength in adulthood.

methodsUsing dual-energy X-ray absorptiometry data from 708 participants (mean age 57 years) in the Midlife in the United States Biomarker Project, we examined the independent associations of composite indices of femoral neck bone strength relative to load (in three failure modes: compression, bending, and impact) in adulthood with the experience of single-parent childhood and parental death or divorce in childhood.

resultsAfter adjustment for gender, race, menopause transition stage, age, and body mass index, each additional year of single-parent childhood was associated with 0.02 to 0.03 SD lower indices of adult femoral neck strength. In those with 9-16 years of single-parent childhood, the compression strength index was 0.41 SD lower, bending strength index was 0.31 SD lower, and impact strength index was 0.25 SD lower (all p values < 0.05). In contrast, parental death or divorce during childhood was not by itself independently associated with adult bone strength indices. The magnitudes of these associations were unaltered by additional adjustment for lifestyle factors and socioeconomic status in childhood and adulthood.

conclusionsIndependent of parental death or divorce, growing up in a single-parent household is associated with lower femoral neck bone strength in adulthood, and this association is not entirely explained by childhood or adult socioeconomic conditions or lifestyle choices.

Indexed as

Single-Parent FamilyAbsorptiometry, PhotonAdultAgedBone DensityChildDivorceFemaleFemur NeckHumansLife Change EventsLife StyleMaleMiddle AgedParental DeathSocial Class

Identifiers

PMID25510582
PMCPMC4344315

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