ArticleBMC complementary and alternative medicine2014
Essential oil of Melaleuca alternifolia for the treatment of oral candidiasis induced in an immunosuppressed mouse model.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Meta-analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections.Journal of applied microbiology · 2022Pooled it
- Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results.Veterinary research communications · 2016Trial
- From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression.MicrobiologyOpen · 2026Review
- Nano-Enabled Advances in Tea Tree Essential Oil (Materials (Basel, Switzerland) · 2026Review
- Essential Oils ofPharmaceutics · 2021Review
- Antibiofilm Potential of Medicinal Plants againstAntibiotics (Basel, Switzerland) · 2021Review
- The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections.Veterinary sciences · 2020Review
- Synergistic interaction of eugenol and antimicrobial drugs in eradication of single and mixed biofilms of Candida albicans and Streptococcus mutans.AMB Express · 2020Article
- Article
- Essential Oils and Their Natural Active Compounds Presenting Antifungal Properties.Molecules (Basel, Switzerland) · 2019Review
- Elucidating the effect of anti-biofilm activity of bioactive compounds extracted from plants.Journal of biosciences · 2019Review
- Article
- Antifungal Activity of Commercial Essential Oils and Biocides against Candida Albicans.Pathogens (Basel, Switzerland) · 2018Article
- An Update onFrontiers in microbiology · 2017Review
- Effect of the Ethyl Acetate Fraction ofFrontiers in microbiology · 2017Article
- Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Review
- The influence ofJournal of Indian Prosthodontic SocietyArticle
- In vitro effects of Melaleuca alternifolia essential oil on growth and production of volatile sulphur compounds by oral bacteria.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe search for alternative therapies for oral candidiasis is a necessity and the use of medicinal plants seems to be one of the promising solutions. The objective of this study was to evaluate the in vitro and in vivo effects of the essential oil of Melaleuca alternifolia on Candida albicans.
methodsThe minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) of M. alternifolia were determined by the broth microdilution assay. For the in vivo study, twelve immunosuppressed mice with buccal candidiasis received topical applications of M. alternifolia with MBEC. After treatment, yeasts were recovered from the mice and quantified (CFU/mL). Mice were killed for morphologic analysis of the tongue dorsum by optical and scanning electron microscopy. Data were analyzed using Student's t test or Mann-Whitney test.
resultsThe MIC of M. alternifolia was 0.195% and the MBEC was 12.5%. Treatment with M. alternifolia achieved a 5.33 log reduction in C. albicans and reduced the microscopic lesions of candidiasis.
conclusionsM. alternifolia oil at a 12.5% was effective to eradicate a C. albicans biofilm formed in vitro and to reduce yeasts of C. albicans in an immunosuppressed mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.