Trial reportPsychoneuroendocrinology2015
Marital discord, past depression, and metabolic responses to high-fat meals: Interpersonal pathways to obesity.
Trial report in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Depression and obesity among females, are sex specificities considered?Archives of women's mental health · 2021Pooled it
- Magnitude and Timing of the Postprandial Inflammatory Response to a High-Fat Meal in Healthy Adults: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- Dietary Soybean vs. Palm Oils Differ in Effects on Liver Fat in Adults With MAFLD: A 16-Week, Double-Masked, Randomized Controlled Trial.Diabetes, obesity & metabolism · 2026Trial
- Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation.Psychoneuroendocrinology · 2018Trial
- Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices.Molecular psychiatry · 2017Trial
- Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women.Molecular nutrition & food research · 2016Trial
- Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial.JMIR research protocols · 2025Article
- "I'm Ready This Time": Investigating physiological and emotional habituation to repetitive social stress.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Is age more than a number? Accounting for adult development and aging in the study of psychoneuroimmunology, stress, and health.Comprehensive psychoneuroendocrinology · 2024Article
- The post-Cartesian dilemma: Reuniting the mind and body through psychoneuroimmunology.Comprehensive psychoneuroendocrinology · 2024Article
- Psychoneuroimmunology and the research of Janice Kiecolt-Glaser: It informs self-care and the practice of medicine.Comprehensive psychoneuroendocrinology · 2024Review
- Turning stress into success: A festschrift in honor of Janice Kiecolt-Glaser.Comprehensive psychoneuroendocrinology · 2024Article
- Couples-based health behavior change interventions: A relationship science perspective on the unique opportunities and challenges to improve dyadic health.Comprehensive psychoneuroendocrinology · 2024Article
- Interpersonal relationships, PNI, and health: Seeds in the 1980s, fruiting trees today.Comprehensive psychoneuroendocrinology · 2024Article
- A social science: Using psychoneuroimmunology principles to promote career longevity, productivity, and meaning.Comprehensive psychoneuroendocrinology · 2024Article
- A healthy balance: the ratio of social support-to-demands is associated with metabolic syndrome.Journal of behavioral medicine · 2024Article
- Your suffering is my stressor: Proinflammatory gene expression rises with spousal distress in middle-aged and older couples.Psychoneuroendocrinology · 2023Article
- Marital negativity's festering wounds: The emotional, immunological, and relational toll of couples' negative communication patterns.Psychoneuroendocrinology · 2023Article
- Conjoint trajectories of couples' marital and parental conflictual behaviors and later-life mental, physical, and relational health.Journal of social and personal relationships · 2022Article
- Frequent Interpersonal Stress and Inflammatory Reactivity Predict Depressive-Symptom Increases: Two Tests of the Social-Signal-Transduction Theory of Depression.Psychological science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLongitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related metabolic responses to high-fat meals.
methodsThis double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, insulin, glucose, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) before and after two high-fat meals. During two separate 9.5h visits, 43 healthy married couples, ages 24-61 (mean=38.22), received either a high saturated fat meal or a high oleic sunflower oil meal, both 930kcal and 60g fat. The Structured Diagnostic Interview for DSM-IV assessed mood disorder history. Couples discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors.
resultsMen and women who displayed more hostile behaviors and who also had a mood disorder history had significantly lower post-meal REE, higher insulin, and higher peak triglyceride responses than other participants, with nonsignificant effects for fat and carbohydrate oxidation. Participants with a mood disorder history had a steeper rise in postprandial IL-6 and glucose than those without a past history. Higher levels of hostile behaviors were associated with higher post-meal TNF-α. The two meals did not differ on any outcome assessed.
conclusionsPeople spend about 18 of every 24h in a postprandial state, and dining with one's partner is a common daily event. Among subjects with a mood disorder history, the cumulative 6.75-h difference between high and low hostile behaviors translates into 128kcal, a difference that could add 7.6pounds/year. Our findings illustrate novel pathways through which chronic marital stress and a mood disorder history synergistically heighten the risk for obesity, metabolic syndrome, and cardiovascular disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.