ArticleNeurobiology of stress2015
Behavioral control blunts reactions to contemporaneous and future adverse events: medial prefrontal cortex plasticity and a corticostriatal network.
Article in Neurobiology of stress, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed.
- Active Avoidance: Neural Mechanisms and Attenuation of Pavlovian Conditioned Responding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Network adaptability governs resilience and susceptibility to social defeat.Molecular psychiatry · 2026Article
- Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway.Molecular psychiatry · 2026Article
- Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health.Translational psychiatry · 2026Article
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Inflexible Orbitofrontal Cortex Functional Connectivity From Rest to Acute Stress in Alcohol Use Disorder.Addiction biology · 2025Article
- Response of parvalbumin interneurons and perineuronal nets in rat medial prefrontal cortex and lateral amygdala to stressor controllability.Brain research · 2025Article
- Neuroscience Education as a Tool for Improving Stress Management and Resilience.Current opinion in behavioral sciences · 2024Article
- Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress.Molecular psychiatry · 2024Article
- Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice.eLife · 2024Article
- Prior experience with behavioral control over stress facilitates social dominance.Neurobiology of stress · 2024Article
- Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat.The international journal of neuropsychopharmacology · 2023Article
- Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress.Stress (Amsterdam, Netherlands) · 2023Article
- Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a Longitudinal Observational Study (DynaM-OBS).JMIR research protocols · 2023Article
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus.Frontiers in integrative neuroscience · 2023Article
- From helplessness to controllability: toward a neuroscience of resilience.Frontiers in psychiatry · 2023Review
- Alcohol's effects during uncertain and uncontrollable stressors in the laboratory.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
It has been known for many years that the ability to exert behavioral control over an adverse event blunts the behavioral and neurochemical impact of the event. More recently, it has become clear that the experience of behavioral control over adverse events also produces enduring changes that reduce the effects of subsequent negative events, even if they are uncontrollable and quite different from the original event controlled. This review focuses on the mechanism by which control both limits the impact of the stressor being experienced and produces enduring, trans-situational "immunization". The evidence will suggest that control is detected by a corticostriatal circuit involving the ventral medial prefrontal cortex (mPFC) and the posterior dorsomedial striatum (DMS). Once control is detected, other mPFC neurons that project to stress-responsive brainstem (dorsal raphe nucleus, DRN) and limbic (amygdala) structures exert top-down inhibitory control over the activation of these structures that is produced by the adverse event. These structures, such as the DRN and amygdala, in turn regulate the proximate mediators of the behavioral and physiological responses produced by adverse events, and so control blunts these responses. Importantly, the joint occurrence of control and adverse events seems to produce enduring plastic changes in the top-down inhibitory mPFC system such that this system is now activated by later adverse events even if they are uncontrollable, thereby reducing the impact of these events. Other issues are discussed that include a) whether other processes such as safety signals and exercise, that lead to resistance/resilience, also use the mPFC circuitry or do so in other ways; b) whether control has similar effects and neural mediation in humans, and c) the relationship of this work to clinical phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.