Evidence map›Paper›PMID 25506581›Full record

ArticleFrontiers in oncology2014

The impact of protocol assignment for older adolescents with hodgkin lymphoma.

Richard S Pieters, Henry Wagner, Stephen Baker, Karen Morano, Kenneth Ulin, Maria Giulia Cicchetti, Maryann Bishop-Jodoin, Thomas J FitzGerald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Hodgkin Lymphoma: Current Status and Clinical Trial Recommendations.Journal of the National Cancer Institute · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Richard S PietersDepartment of Radiation Oncology, University of Massachusetts Medical School, University of Massachusetts Memorial Health Care System , Worcester, MA , USA.
Henry WagnerDivision of Radiation Oncology, Milton S. Hershey Medical Center, Pennsylvania State University , Hershey, PA , USA.
Stephen BakerDepartment of Quantitative Health Sciences and Cell Biology, University of Massachusetts Medical School , Worcester, MA , USA.
Karen MoranoDepartment of Radiation Oncology, Quality Assurance Review Center, University of Massachusetts Medical School , Lincoln, RI , USA.
Kenneth UlinDepartment of Radiation Oncology, University of Massachusetts Medical School, University of Massachusetts Memorial Health Care System , Worcester, MA , USA ; Department of Radiation Oncology, Quality Assurance Review Center, University of Massachusetts Medical School , Lincoln, RI , USA.
Maria Giulia CicchettiDepartment of Radiation Oncology, University of Massachusetts Medical School, University of Massachusetts Memorial Health Care System , Worcester, MA , USA ; Department of Radiation Oncology, Quality Assurance Review Center, University of Massachusetts Medical School , Lincoln, RI , USA.
Maryann Bishop-JodoinDepartment of Radiation Oncology, Quality Assurance Review Center, University of Massachusetts Medical School , Lincoln, RI , USA.
Thomas J FitzGeraldDepartment of Radiation Oncology, University of Massachusetts Medical School, University of Massachusetts Memorial Health Care System , Worcester, MA , USA ; Department of Radiation Oncology, Quality Assurance Review Center, University of Massachusetts Medical School , Lincoln, RI , USA.
University of Massachusetts Chan Medical School · USPennsylvania State University · US

Funding

QUALITY ASSURANCE REVIEW CENTER (QARC)U10CA029511 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, THOMAS J. · 1985 to 2013
$23.4M
NCI NIH HHS U10 CA029511
6 · The paper itself

Abstract

background and purposeHodgkin lymphoma (HL) treatment has evolved to reduce or avoid radiotherapy (RT) dose and volume and minimize the potential for late effects. Some older adolescents are treated on adult protocols. The purpose of this study is to examine the protocol assignment of older adolescents and its impact on radiation dose to relevant thoracic structures. MATERIALS AND

methodsCooperative group data were reviewed and 12 adolescents were randomly selected from a pediatric HL protocol. Treatment plans were generated per one pediatric and two adult protocols. Dose volume histograms for heart, lung, and breast allowed comparison of radiation dose to these sites across these three protocols.

resultsA total of 15.2% of adolescents were treated on adult HL protocols and received significantly higher radiation dosage to heart and lung compared to pediatric HL protocols. Adolescents treated on either pediatric or adult protocols received similar RT dose to breast.

conclusionOlder adolescents treated on adult HL protocols received higher RT dose to thoracic structures except breast. Level of nodal involvement may impact overall RT dose to breast. The impact of varying field design and RT dose on survival, local, and late effects needs further study for this vulnerable age group. Adolescents, young adults, Hodgkin lymphoma, RT, clinical trials.

Indexed as

adolescentsclinical trialsHodgkin lymphomaradiotherapyyoung adults

Identifiers

PMID25506581
PMCPMC4246660
OpenAlexW2163422273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.