Evidence map›Paper›PMID 25506544›Full record

ArticleJournal of obsessive-compulsive and related disorders2014

The Inheritance of Tourette Disorder: A review.

David L Pauls, Thomas V Fernandez, Carol A Mathews, Matthew W State, Jeremiah M Scharf

Open access · greenAbstract read
In one paragraph

Article in Journal of obsessive-compulsive and related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Identifying Distinct Tourette Disorder Subtypes using Clinical Data.medRxiv : the preprint server for health sciences · 2025
    Article
  6. Article
  7. Epigenome-wide Association Study for Tic Disorders in Children: A Preliminary Study in Korean Population.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
  8. Article
  9. Lack of Association ofNeuropsychiatric disease and treatment · 2022
    Article
  10. Review
  11. Article
  12. A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021
    Review
  13. Article
  14. Networks in the Field of Tourette Syndrome.Frontiers in neurology · 2021
    Review
  15. Article
  16. Article
  17. Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

David L PaulsDepartment of Psychiatry, Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114.
Thomas V FernandezChild Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520.
Carol A MathewsDepartment of Psychiatry, University of California, San Francisco, CA 94143.
Matthew W StateDepartment of Psychiatry, University of California, San Francisco, CA 94143.
Jeremiah M ScharfDepartment of Psychiatry, Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114 ; Department of Neurology, Harvard Medical School, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114.
Center for Human Genetics · USUniversity of California, San Francisco · USYale University · US

Funding

A GENETIC LINKAGE STUDY OF GTSR01NS040024 · NINDS · TOURETTE SYNDROME ASSOCIATION, INC · PI PAULS, DAVID L · 2000 to 2004
$9.5M
GENETICS OF TOURETTE SYNDROMER01NS016648 · NINDS · YALE UNIVERSITY · PI PAULS, DAVID L · 1985 to 2009
$9.0M
A Genetic Linkage Study of GTSU01NS040024 · NINDS · TOURETTE ASSOCIATION OF AMERICA, INC. · PI SCHARF, JEREMIAH M · 2007 to 2012
$8.0M
Research Training for Medical Students & Physician-Scientists in Child PsychiatryR25MH077823 · NIMH · YALE UNIVERSITY · PI ANDRES S MARTIN · 2006 to 2026
$4.0M
Refining the Tourette Syndrome phenotype across diagnoses to aid gene discoveryR01MH096767 · NIMH · UNIVERSITY OF FLORIDA · PI MATHEWS, CAROL A · 2013 to 2015
$1.2M
Advancing Tourette Syndrome genetics using bioinformatics and genome biologyK02NS085048 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2014 to 2018
$1.0M
Translational phenomics and genomics of Gilles de la Tourette SyndromeK23MH085057 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2009 to 2013
$929k
2/8-Collaborative genomic studies of Tourette DisorderR01MH092289 · NIMH · YALE UNIVERSITY · PI STATE, MATTHEW W. · 2011 to 2013
$898k
Genomic Investigations of Tourette's DisorderK08MH099424 · NIMH · YALE UNIVERSITY · PI FERNANDEZ, THOMAS V · 2012 to 2015
$718k
NIMH NIH HHS K08 MH099424NIMH NIH HHS K23 MH085057NIMH NIH HHS R01 MH092289NIMH NIH HHS R01 MH096767NIMH NIH HHS R25 MH077823NINDS NIH HHS K02 NS085048NINDS NIH HHS R01 NS016648NINDS NIH HHS R01 NS040024NINDS NIH HHS U01 NS040024
6 · The paper itself

Abstract

Georges Gilles de la Tourette, in describing the syndrome that now bears his name, observed that the condition aggregated within families. Over the last three decades, numerous studies have confirmed this observation, and demonstrated that familial clustering is due in part to genetic factors. Recent studies are beginning to provide clues about the underlying genetic mechanisms important for the manifestation of some cases of Tourette Disorder (TD). Evidence has come from different study designs, such as nuclear families, twins, multigenerational families, and case-control samples, together examining the broad spectrum of genetic variation including cytogenetic abnormalities, copy number variants, genome-wide association of common variants, and sequencing studies targeting rare and/or

Indexed as

ADHDGeneticsOCDReviewTourette Disorder

Identifiers

PMID25506544
PMCPMC4260404
OpenAlexW1995515744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.