ArticleSurgical neurology international2014
Neonatal pain: What's age got to do with it?
Article in Surgical neurology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.The Cochrane database of systematic reviews · 2025Pooled it
- Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.The Cochrane database of systematic reviews · 2024Pooled it
- Maternal facilitated tucking versus nurse facilitated tucking for alleviation of pain during neonatal heel lancing: A randomised, two-period, cross-over trial.The Indian journal of medical research · 2026Trial
- Effect of pacifier and pacifier with dextrose in reducing pain during orogastric tube insertion in newborns: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2024Trial
- New perspective for pain control in neonates: a comparative effectiveness research.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Oxidative Stress as a Physiological Pain Response in Full-Term Newborns.Oxidative medicine and cellular longevity · 2017Trial
- Use of Tramadol in Pain Management of Neonates with Epidermolysis Bullosa: A Single-Center Experience.Children (Basel, Switzerland) · 2026Article
- Origins and Previous Experiences from a Gender Perspective on the Perception of Pain in Nursing Students: Study Protocol.Healthcare (Basel, Switzerland) · 2025Article
- Listening to the lost voices: a qualitative study reflecting on medical assistance in dying for mature minors in Ontario.Paediatrics & child health · 2025Article
- Efficacy of Dextrose Versus Breast Milk on Pain and Comfort in Neonates Undergoing Heel Lance: A Pilot Study.Cureus · 2025Article
- The intersection of endocrine signaling and neuroimmune communication regulates muscle inflammation-induced nociception in neonatal mice.Brain, behavior, and immunity · 2025Article
- A conceptual model for assessing the risk of unidentified pain.The journal of pain · 2025Article
- Local Lidocaine-Prilocaine for Immunisation in Infants.Vaccines · 2024Review
- Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Intertemporal Improvement in Physicians' Perceptions of the Short-Term Adverse Outcomes of Neonatal Pain: Results of a Two-Time-Point National Survey.Children (Basel, Switzerland) · 2024Article
- The relationship between neonatal stress in preterm infants and developmental outcomes at the corrected age of 24-30 months.Frontiers in psychology · 2024Article
- Cortisol levels are related to neonatal pain exposure in children born very preterm at age 18 months in two independent cohorts.Paediatric & neonatal pain · 2023Article
- Skin-to-skin contact-An effective intervention on pain and stress reduction in preterm infants.Frontiers in pediatrics · 2023Article
- The fetal pain paradox.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Association of Neonatal Pain-Related Stress and Parent Interaction With Internalizing Behaviors Across 1.5, 3.0, 4.5, and 8.0 Years in Children Born Very Preterm.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neurobiology of neonatal pain processing, especially in preterm infants, differs significantly from older infants, children, adolescence, and adults. Research suggests that strong painful procedures or repeated mild procedures may permanently modify individual pain processing. Acute injuries at critical developmental periods are risk factors for persistent altered neurodevelopment. The purpose of this narrative review is to present the seminal and current literature describing the unique physiological aspects of neonatal pain processing.
methodsArticles describing the structures and physiological processes that influence neonatal pain were identified from electronic databases Medline, PubMed, and CINAHL.
resultsThe representation of neonatal pain physiology is described in three processes: Local peripheral nervous system processes, referred to as transduction; spinal cord processing, referred to as transmission and modulation; and supraspinal processing and integration or perception of pain. The consequences of undermanaged pain in preterm infants and neonates are discussed.
conclusionAlthough the process and pain responses in neonates bear some similarity to processes and pain responses in older infants, children, adolescence, and adults; there are some pain processes and responses that are unique to neonates rendering them at risk for inadequate pain treatment. Moreover, exposure to repeated painful stimuli contributes to adverse long-term physiologic and behavioral sequelae. With the emergence of studies showing that painful experiences are capable of rewiring the adult brain, it is imperative that we treat neonatal pain effectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.