Evidence map›Paper›PMID 25506471›Full record

ArticleBone research

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts.

Thomas S Lisse, Kanagasabai Vadivel, S Paul Bajaj, Rene F Chun, Martin Hewison, John S Adams

Open access · goldAbstract read
In one paragraph

Article in Bone research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mitochondrial Factors in the Cell Nucleus.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Vitamin D and alternative splicing of RNA.The Journal of steroid biochemistry and molecular biology · 2015
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas S LisseDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
Kanagasabai VadivelDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
S Paul BajajDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
Rene F ChunDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
Martin HewisonDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
John S AdamsDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA, Los Angeles, CA 90095 USA.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
VITAMIN D RESISTANCE: MONKEY TO MANR01AR037399 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ADAMS, JOHN S · 1988 to 2013
$4.3M
NCI NIH HHS P30 CA016042NIAMS NIH HHS R01 AR037399NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

Heterogeneous nuclear ribonucleoprotein (hnRNP) C plays a key role in RNA processing. More recently hnRNP C has also been shown to function as a DNA binding protein exerting a dominant-negative effect on transcriptional responses to the vitamin D hormone,1,25-dihydroxyvitamin D (1,25(OH)

Identifiers

PMID25506471
PMCPMC4261231
OpenAlexW2034989215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.