Evidence map›Paper›PMID 25506416›Full record

ArticleAnnali di stomatologia2014

Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature.

Erlind Pepla, Lait Kostantinos Besharat, Gaspare Palaia, Gianluca Tenore, Guido Migliau

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Annali di stomatologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04887389 (Cariostatic and Remineralizing Effects of Three Different Dental Varnishes), which is not on this map. Cited by 124 papers.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04887389 phase4completednot on this mapstarted 2021, after this paper: background citation

Cariostatic and Remineralizing Effects of Three Different Dental Varnishes (A Clinical Trial)

TypeinterventionalSponsorNisreen Ibrahim khanRan2021 to 2023Enrolled115ConditionsDental Caries in Children, Cariostatic Agent, Resistance, Dental Caries, Fluoride VarnishesArmsNano Silver Fluoride varnish, nano-hydroxyapatite varnish, sodium Fluoride Varnish
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 306 citations in OpenAlex.

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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erlind PeplaDepartment of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
Lait Kostantinos BesharatDepartment of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
Gaspare PalaiaDepartment of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
Gianluca TenoreDepartment of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
Guido MigliauDepartment of Oral and Maxillo-Facial Sciences, "Sapienza" University of Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to critically summarize the literature about nano-hydroxyapatite. The purpose of this work is to analyze the benefits of using nano-hydroxyapatite in dentistry, especially for its preventive, restorative and regenerative applications. We also provide an overview of new dental materials, still experimental, which contain the nano-hydroxyapatite in its nano-crystalline form. Hydroxyapatite is one of the most studied biomaterials in the medical field for its proven biocompatibility and for being the main constituent of the mineral part of bone and teeth. In terms of restorative and preventive dentistry, nano-hydroxyapatite has significant remineralizing effects on initial enamel lesions, certainly superior to conventional fluoride, and good results on the sensitivity of the teeth. The nano-HA has also been used as an additive material, in order to improve already existing and widely used dental materials, in the restorative field (experimental addition to conventional glass ionomer cements, that has led to significant improvements in their mechanical properties). Because of its unique properties, such as the ability to chemically bond to bone, to not induce toxicity or inflammation and to stimulate bone growth through a direct action on osteoblasts, nano-HA has been widely used in periodontology and in oral and maxillofacial surgery. Its use in oral implantology, however, is a widely used practice established for years, as this substance has excellent osteoinductive capacity and improves bone-to-implant integration.

Indexed as

nano-HApreventiveregenerativerestorative

Identifiers

PMID25506416
PMCPMC4252862
OpenAlexW2092927148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.