ReviewFrontiers in neurology2014
Clinical features in patients with long-lasting macrophagic myofasciitis.
Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications.Clinical and experimental immunology · 2023Review
- Critical evaluation on roles of macrophagic myofasciitis and aluminum adjuvants in HPV vaccine-induced adverse events.Cancer science · 2023Review
- Colloidal Manganese Salt Improves the Efficacy of Rabies Vaccines in Mice, Cats, and Dogs.Journal of virology · 2021Article
- Cytokines profile in neonatal and adult wild-type mice post-injection of U. S. pediatric vaccination schedule.Brain, behavior, & immunity - health · 2021Article
- Relative Incidence of Office Visits and Cumulative Rates of Billed Diagnoses Along the Axis of Vaccination.International journal of environmental research and public health · 2020Article
- Causality assessment of adverse events following immunization: the problem of multifactorial pathology.F1000Research · 2020Article
- Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach.Reumatologia · 2020Article
- Aluminium toxicosis: a review of toxic actions and effects.Interdisciplinary toxicology · 2019Review
- Macrophagic myofasciitis: a challenging diagnosis.BMJ case reports · 2018Article
- Revised World Health Organization (WHO)'s causality assessment of adverse events following immunization-a critique.F1000Research · 2018Article
- Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series.Clinical rheumatology · 2017Review
- Predictive value of brain 18F-FDG PET/CT in macrophagic myofasciitis?: A case report.Medicine · 2017Article
- Diagnostic confounders of chronic widespread pain: not always fibromyalgia.Pain reports · 2017Review
- Morin Stain Detects Aluminum-Containing Macrophages in Macrophagic Myofasciitis and Vaccination Granuloma With High Sensitivity and Specificity.Journal of neuropathology and experimental neurology · 2017Article
- Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil.Immunologic research · 2017Article
- Article
- Re: Proposed HPV vaccination syndrome is unsubstantiated.Clinical rheumatology · 2016Article
- FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis.Nuclear medicine and molecular imaging · 2016Article
- HPV vaccination syndrome. A questionnaire-based study.Clinical rheumatology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and marked cognitive deficits, not related to pain, fatigue, or depression. Clinical features usually correspond to that observed in chronic fatigue syndrome/myalgic encephalomyelitis. Representative features of MMF-associated cognitive dysfunction include dysexecutive syndrome, visual memory impairment, and left ear extinction at dichotic listening test. Most patients fulfill criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits appear unusually severe. Cognitive dysfunction seems stable over time despite marked fluctuations. Evoked potentials may show abnormalities in keeping with central nervous system involvement, with a neurophysiological pattern suggestive of demyelination. Brain perfusion SPECT shows a pattern of diffuse cortical and subcortical abnormalities, with hypoperfusions correlating with cognitive deficiencies. The combination of musculoskeletal pain, chronic fatigue, and cognitive disturbance generates chronic disability with possible social exclusion. Classical therapeutic approaches are usually unsatisfactory making patient care difficult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.