ArticleFrontiers in human neuroscience2014
Schizophrenia and cortical blindness: protective effects and implications for language.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Congenital blindness does not protect against a schizophrenia-related phenotype in rodents.Schizophrenia research · 2023Article
- Nonlinear functional network connectivity in resting functional magnetic resonance imaging data.Human brain mapping · 2022Article
- Evidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway.Schizophrenia bulletin · 2022Article
- Eyes, the window on psychosis?BJPsych open · 2022Article
- Patients with first-episode untreated schizophrenia who experience concomitant visual disturbances and auditory hallucinations exhibit co-impairment of the brain and retinas-a pilot study.Brain imaging and behavior · 2021Article
- Is Early Blindness Protective of Psychosis or Are We Turning a Blind Eye to the Lack of Statistical Power?Schizophrenia bulletin · 2020Article
- Blindness, Psychosis, and the Visual Construction of the World.Schizophrenia bulletin · 2020Article
- Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia.Journal of psychiatry and brain science · 2020Article
- A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms.NeuroImage. Clinical · 2019Article
- Schizophrenia and Infections: The Eyes Have It.Schizophrenia bulletin · 2017Review
- Possible functional links among brain- and skull-related genes selected in modern humans.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repeatedly noted absence of case-reports of individuals with schizophrenia and congenital/early developed blindness has led several authors to argue that the latter can confer protective effects against the former. In this work, we present a number of relevant case-reports from different syndromes that show comorbidity of congenital and early blindness with schizophrenia. On the basis of these reports, we argue that a distinction between different types of blindness in terms of the origin of the visual deficit, cortical or peripheral, is crucial for understanding the observed patterns of comorbidity. We discuss the genetic underpinnings and the brain structures involved in schizophrenia and blindness, with insights from language processing, laying emphasis on the three structures that particularly stand out: the occipital cortex, the lateral geniculate nucleus (LGN), and the pulvinar. Last, we build on previous literature on the nature of the protective effects in order to offer novel insights into the nature of the protection mechanism from the perspective of the brain structures involved in each type of blindness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.