ArticleFrontiers in behavioral neuroscience2014
Impairments of working memory in schizophrenia and bipolar disorder: the effect of history of psychotic symptoms and different aspects of cognitive task demands.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The effects of caffeine and d-amphetamine on spatial span task in healthy participants.PloS one · 2023Trial
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice.Translational psychiatry · 2024Article
- Double dissociation between P300 components and task switch error type in healthy but not psychosis participants.Schizophrenia research · 2023Article
- The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- Age-related differences in transient gamma band activity during working memory maintenance through adolescence.NeuroImage · 2023Article
- Copy Number Variations and Schizophrenia.Molecular neurobiology · 2023Review
- The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders.Brain sciences · 2021Article
- Neurocognition in Kenyan youth at clinical high risk for psychosis.Schizophrenia research. Cognition · 2021Article
- Are working memory and glutamate concentrations involved in early-life stress and severity of psychosis?Brain and behavior · 2020Article
- How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.Annals of general psychiatry · 2020Review
- Neurocognitive impairment and evidence-based treatment options in Bipolar disorder.Annals of general psychiatry · 2020Review
- Working Memory Impairment Across Psychotic disorders.Schizophrenia bulletin · 2019Article
- Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia.Pharmacology research & perspectives · 2019Article
- Stress, Allostatic Load, and Psychosis: One Step Forward in Research But Where to Go Next?Frontiers in psychiatry · 2019Article
- Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.Neuropsychology review · 2018Review
- Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory.Schizophrenia research · 2018Article
- [Neuropsychological Profile and Working Memory in Bipolar Disorder].Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Article
- Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
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Authors and funding
9 authors.
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Abstract
Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic BPD (n = 24), as well as to healthy controls (HC) (n = 18) in order to compare the level of WM impairments across the groups. With respect to the less demanding WM measures (Digit Span Forward and Backward, Short-delay CPT-AX), there were no between group differences in cognitive performance; however, with respect to the more demanding WM measures (Long-delay CPT-AX, N-back), we observed that the groups with psychosis (SZ, psychotic BPD) did not differ from one another, but performed poorer than the group without a history of psychosis (non-psychotic BPD). A history of psychotic symptoms may influence cognitive performance with respect to WM delay and load effects as measured by Long-delay CPT-AX and N-back tests, respectively. We observed a positive correlation of WM performance with antipsychotic treatment and a negative correlation with depressive symptoms in BPD and with negative symptoms in SZ subgroup. Our study suggests that WM dysfunctions are more closely related to a history of psychosis than to the diagnostic categories of SZ and BPD described by psychiatric classification systems.
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