ArticleFrontiers in behavioral neuroscience2014
Medial prefrontal cortex dopamine controls the persistent storage of aversive memories.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Emerging Functions of Neuromodulation during Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Enhanced Risky Choice in Male Rats Elicited by the Acute Pharmacological Stressor Yohimbine Involves Prefrontal Dopamine D1 Receptor Activation.The international journal of neuropsychopharmacology · 2024Article
- Involvement of cortical input to the rostromedial tegmental nucleus in aversion to foot shock.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Brain-Wide Projections and Differential Encoding of Prefrontal Neuronal Classes Underlying Learned and Innate Threat Avoidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Fentanyl-induced reward seeking is sex and dose dependent and is prevented by D-cysteine ethylester.Frontiers in pharmacology · 2023Article
- Dopamine Modulates Adaptive Forgetting in Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Review
- Article
- Inhibitory learning of phototaxis by honeybees in a passive-avoidance task.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Hippocampus and Prefrontal Cortex Modulation of Contextual Fear Memory Is Dissociated by Inhibiting De Novo Transcription During Late Consolidation.Molecular neurobiology · 2019Article
- Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation.Cellular and molecular life sciences : CMLS · 2018Review
- The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans.Molecular neurobiology · 2018Review
- mTORC1 controls long-term memory retrieval.Scientific reports · 2018Article
- Neural, Cellular and Molecular Mechanisms of Active Forgetting.Frontiers in systems neuroscience · 2018Review
- Activation of D1/5 Dopamine Receptors in the Dorsal Medial Prefrontal Cortex Promotes Incubated-Like Aversive Responses.Frontiers in behavioral neuroscience · 2017Article
- Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala.Molecular psychiatry · 2016Article
- Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System.eNeuroArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medial prefrontal cortex (mPFC) is essential for initial memory processing and expression but its involvement in persistent memory storage has seldom been studied. Using the hippocampus dependent inhibitory avoidance learning task and the hippocampus-independent conditioned taste aversion paradigm together with specific dopamine receptor agonists and antagonists we found that persistence but not formation of long-term aversive memories requires dopamine D1/D5 receptors activation in mPFC immediately after training and, depending on the task, between 6 and 12 h later. Our results indicate that besides its well-known participation in retrieval and early consolidation, mPFC also modulates the endurance of long-lasting aversive memories regardless of whether formation of the aversive mnemonic trace requires the participation of the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.