ArticleMolecular breeding : new strategies in plant improvement2014
Crossbreeding of transgenic flax plants overproducing flavonoids and glucosyltransferase results in progeny with improved antifungal and antioxidative properties.
Article in Molecular breeding : new strategies in plant improvement, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Constitutive Expression of AtVTE2 in Flax Is Associated with Changes in Isoprenoid Metabolism and Stem Cell-Wall Composition.International journal of molecular sciences · 2026Article
- Genetic mapping identifies QTL and candidate genes including Mendel's A gene controlling high levels of partial resistance to Fusarium avenaceum in Pea.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Integrated metabolome and transcriptome analysis reveals the potential mechanism of anthocyanin biosynthesis inFrontiers in plant science · 2026Article
- Comprehensive metabolome characterization of leaves, internodes, and aerial roots of Vanilla planifolia by untargeted LC-MS and GC × GC-MS.Phytochemical analysis : PCA · 2025Article
- Relationship Between the Structure of the FlavoneMolecules (Basel, Switzerland) · 2024Article
- Overexpression of Bacterial Beta-Ketothiolase Improves Flax (Metabolites · 2023Article
- Phenolic Compound Profile and Antioxidant Capacity of Flax (Molecules (Basel, Switzerland) · 2023Article
- Anthocyanins fromFrontiers in microbiology · 2023Article
- Commonly and Specifically Activated Defense Responses in Maize Disease Lesion Mimic Mutants Revealed by Integrated Transcriptomics and Metabolomics Analysis.Frontiers in plant science · 2021Article
- 3-Hydroxybutyrate Is Active Compound in Flax That Upregulates Genes Involved in DNA Methylation.International journal of molecular sciences · 2020Article
- Comparative proteomics analysis of Tibetan hull-less barley under osmotic stress via data-independent acquisition mass spectrometry.GigaScience · 2020Article
- Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from in Vitro Plant Cultures.Plants (Basel, Switzerland) · 2020Review
- The Chalcone Isomerase Family in Cotton: Whole-Genome Bioinformatic and Expression Analyses of theGenes · 2019Article
- Endogenous and Exogenous Modulation of Nrf2 Mediated Oxidative Stress Response in Bovine Granulosa Cells: Potential Implication for Ovarian Function.International journal of molecular sciences · 2019Article
- Characterization of a heat responsive UDP: Flavonoid glucosyltransferase gene in tea plant (Camellia sinensis).PloS one · 2018Article
- Close and distant: Contrasting the metabolism of two closely related subspecies of Scots pine under the effects of folivory and summer drought.Ecology and evolution · 2017Article
- Flavonoid Accumulation Plays an Important Role in the Rust Resistance ofFrontiers in plant science · 2017Article
- Flavones: From Biosynthesis to Health Benefits.Plants (Basel, Switzerland) · 2016Review
- Methyl Salicylate Level Increase in Flax afterFrontiers in plant science · 2016Article
- Flavonoid C-glucosides Derived from Flax Straw Extracts Reduce Human Breast Cancer Cell Growth In vitro and Induce Apoptosis.Frontiers in pharmacology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids are a large group of secondary plant metabolites with many important functions; they play a role in fruit, flower and seed pigmentation and are involved in multiple protective mechanisms. They are very active natural antioxidants, acting as antimicrobial compounds in defense against pathogens, and they protect the plant against various stress factors, including excessive solar radiation and temperature. They are also an animal deterrent. Flax is already a very useful crop plant with nutritional and biomedical applications. With increased phenylpropanoid content, flax plants could be used in the production of improved dietary supplements and antimicrobial agents. The main aim of this study was to engineer a flax variety with increased flavonoid content by crossing two transgenic flax varieties that have heightened flavonoid levels. A mother plant that over expresses genes encoding the flavonoid biosynthesis pathway enzymes chalcone synthase, chalcone isomerase and dihydroflavonol reductase was crossed with plants overexpressing the glucosyltransferase (GT) gene. It was expected that the progeny would display better properties thanks to the simultaneous increases in flavonoid synthesis and stability. In comparison to the control and parental plants, plants of the selected flax lines were found to have increased contents of flavonoids and other phenylpropanoids, including phenolic acids, in their stems and seeds. A significant increase in the secoisolariciresinol diglucoside content was found in the seeds. The antioxidative properties of extracts from W92 × GT crossbreed plants were higher than the control (non-transgenic) and parental plants. These results correlated with the increase in the susceptibility of the crossbreeds to
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