ReviewThe application of clinical genetics2014
New insights into the genetic basis of infertility.
Review in The application of clinical genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Statistical methods to disentangle genetic effects influencing infertility and early fetal viability with a genome-wide application.PLoS genetics · 2025Article
- Individual effects of GSTM1 and GSTT1 polymorphisms on the risk of polycystic ovarian syndrome: A systematic review and meta-analysis.Turkish journal of obstetrics and gynecology · 2023Article
- Evaluation of Azoospermic Patients to Distinguish Obstructive from Non-Obstructive Azoospermia, and Necessity of Diagnostic Testis Biopsy: A Retrospective Study.International journal of fertility & sterility · 2022Article
- Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation.Cell stem cell · 2022Article
- Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection.Infectious agents and cancer · 2021Review
- Article
- Genetics in human reproduction.JBRA assisted reproduction · 2020Review
- A prospective study of treatments for cervical intraepithelial neoplasia and fecundability.American journal of obstetrics and gynecology · 2020Article
- Protein phosphatase 6 is a key factor regulating spermatogenesis.Cell death and differentiation · 2020Article
- Genetic diagnosis of subfertility: the impact of meiosis and maternal effects.Journal of medical genetics · 2019Review
- Article
- Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?Archives of endocrinology and metabolism · 2019Article
- Autosomal single-gene disorders involved in human infertility.Saudi journal of biological sciences · 2018Article
- Developmental Programming of Ovarian Functions and Dysfunctions.Vitamins and hormones · 2018Review
- Unraveling transcriptome dynamics in human spermatogenesis.Development (Cambridge, England) · 2017Article
- Mutations of SGO2 and CLDN14 collectively cause coincidental Perrault syndrome.Clinical genetics · 2017Article
- Genome-wide analysis identifies 12 loci influencing human reproductive behavior.Nature genetics · 2016Article
- Review
- Single Gene and Syndromic Causes of Obesity: Illustrative Examples.Progress in molecular biology and translational science · 2016Review
- Androgen receptor (AR) gene CAG trinucleotide repeat length associated with body composition measures in non-syndromic obese, non-obese and Prader-Willi syndrome individuals.Journal of assisted reproduction and genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a disease of the reproductive system characterized by inability to achieve pregnancy after 12 or more months of regular unprotected sexual intercourse. A variety of factors, including ovulation defects, spermatogenic failure, parental age, obesity, and infections have been linked with infertility, in addition to specific karyotypes and genotypes. The study of genes associated with infertility in rodent models has expanded the field of translational genetics in identifying the underlying cause of human infertility problems. Many intriguing aspects of the molecular basis of infertility in humans remain poorly understood; however, application of genetic knowledge in this field looks promising. The growing literature on the genetics of human infertility disorders deserves attention and a critical concise summary is required. This paper provides information obtained from a systematic analysis of the literature related to current research into the genetics of infertility affecting both sexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.