ArticleClinicoEconomics and outcomes research : CEOR2014
Seriousness, preventability, and burden impact of reported adverse drug reactions in Lombardy emergency departments: a retrospective 2-year characterization.
Article in ClinicoEconomics and outcomes research : CEOR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Potential Direct Costs of Adverse Drug Events and Possible Cost Savings Achievable by their Prevention in Tuscany, Italy: A Model-Based Analysis.Drug safety · 2019Pooled it
- Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review.PloS one · 2019Pooled it
- A Two-Year Pharmacovigilance Analysis of Adverse Drug Reactions Reported from a University Allergy Setting.Journal of clinical medicine · 2026Article
- Characteristics, preventability, management, and predictors of adverse drug reaction-related hospital admissions: a cross-sectional study in a Thai tertiary care hospital.Journal of pharmaceutical policy and practice · 2026Article
- Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population.International journal of clinical pharmacy · 2024Article
- Prevalence and factors associated with adverse drug reactions among heart failure patients hospitalized at Mbarara Regional Referral Hospital, Uganda.BMC cardiovascular disorders · 2022Observational
- Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study.Journal of clinical medicine · 2022Article
- Pharmacovigilance and Pharmacoepidemiology as a Guarantee of Patient Safety: The Role of the Clinical Pharmacologist.Journal of clinical medicine · 2022Article
- Medication-related adverse events in health care-what have we learned? A narrative overview of the current knowledge.European journal of clinical pharmacology · 2022Review
- Causality and avoidability of adverse drug reactions of antibiotics in hospitalized children: a cohort study.International journal of clinical pharmacy · 2021Article
- Analysis of fatal adverse drug events recorded in several Italian emergency departments (the MEREAFaPS study).Internal and emergency medicine · 2021Article
- Preventable adverse drug events causing hospitalisation: identifying root causes and developing a surveillance and learning system at an urban community hospital, a cross-sectional observational study.BMJ open quality · 2021Observational
- Risk of Hospitalization Associated with Cardiovascular Medications in the Elderly Italian Population: A Nationwide Multicenter Study in Emergency Departments.Frontiers in pharmacology · 2020Article
- Serious Inadequacies in High Alert Medication-Related Knowledge Among Pakistani Nurses: Findings of a Large, Multicenter, Cross-sectional Survey.Frontiers in pharmacology · 2020Article
- Immune Checkpoint Inhibitors and Immune-Related Adverse Drug Reactions: Data From Italian Pharmacovigilance Database.Frontiers in pharmacology · 2020Article
- Italian Emergency Department Visits and Hospitalizations for Outpatients' Adverse Drug Events: 12-Year Active Pharmacovigilance Surveillance (The MEREAFaPS Study).Frontiers in pharmacology · 2020Article
- Characterization and preventability of adverse drug events as cause of emergency department visits: a prospective 1-year observational study.BMC pharmacology & toxicology · 2019Observational
- Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review.Therapeutic advances in drug safety · 2019Review
- Preventability of serious thromboembolic and bleeding events related to the use of oral anticoagulants: a prospective study.British journal of clinical pharmacology · 2018Observational
- Characterization of serious adverse drug reactions as cause of emergency department visit in children: a 5-years active pharmacovigilance study.BMC pharmacology & toxicology · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to determine the prevalence of adverse drug reactions (ADRs) reported in emergency departments (EDs) and carry out a thorough characterization of these to assess preventability, seriousness that required hospitalization, subsequent 30-day mortality, and economic burden.
methodsThis was a retrospective cohort study of data from an active pharmacovigilance project at 32 EDs in the Lombardy region collected between January 1, 2010 and December 31, 2011. Demographic, clinical, and pharmacological data on patients admitted to EDs were collected by trained and qualified monitors, and deterministic record linkage was performed to estimate hospitalizations. Pharmacoeconomic analyses were based on Diagnosis-Related Group reimbursement.
results8,862 ADRs collected with an overall prevalence rate of 3.5 per 1,000 visits. Of all ADRs, 42% were probably/definitely preventable and 46.4% were serious, 15% required hospitalization, and 1.5% resulted in death. The System Organ Classes most frequently associated with ADRs were: skin and subcutaneous tissue, gastrointestinal, respiratory thoracic and mediastinal, and nervous system disorders. The most common Anatomical Therapeutic Chemical classes involved in admissions were J (anti-infectives and immunomodulating agents), B (blood and blood-forming organs), and N (nervous system). Older age, yellow and red triage, higher number of concomitantly taken drugs, and previous attendance in ED for the same ADR were significantly associated with an increased risk of hospitalization. The total cost associated with ADR management was €5,184,270, with a mean cost per patient of €585. Fifty-eight percent of the economic burden was defined as probably/definitely preventable.
conclusionADRs are a serious health/economic issue in EDs. This assessment provides a thorough estimation of their seriousness, preventability, and burden impact in a large population from a representative European region.
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