ArticleOxidative medicine and cellular longevity2014
Evaluation of neonatal streptozotocin induced diabetic rat model for the development of cataract.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Phenolic Profile, Antioxidant Potential, and Antidiabetic Effects of Aristolochia longa Extracts in Streptozotocin-Induced Diabetic Rats.Chemistry & biodiversity · 2026Article
- A Review of Animal Models for Studying Bone Health in Type-2 Diabetes Mellitus (T2DM) and Obesity.International journal of molecular sciences · 2024Review
- Quantification of Photoreceptors' Changes in a Diabetic Retinopathy Model with Two-Photon Imaging Microscopy.International journal of molecular sciences · 2024Article
- Glutamate is effective in decreasing opacity formed in galactose-induced cataract model.Scientific reports · 2024Article
- Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats.Frontiers in pharmacology · 2024Article
- Self-nanoemulsifying Delivery of Andrographolide: Ameliorating Islet Beta Cells and Inhibiting Adipocyte Differentiation.Advanced pharmaceutical bulletin · 2021Article
- Cinnamon Attenuated Long-Term IGT-Induced Retinal Abnormalities via Regulation of Glucose Homeostasis in Neonatal Streptozotocin Induced Rat Model.Indian journal of clinical biochemistry : IJCB · 2020Article
- Olfactory Dysfunction in Diabetic Rats is Associated with miR-146a Overexpression and Inflammation.Neurochemical research · 2020Article
- Bisamide Derivative of Dicarboxylic Acid Contributes to Restoration of Testicular Tissue Function and Influences Spermatogonial Stem Cells in Metabolic Disorders.Frontiers in cell and developmental biology · 2020Article
- Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes.Archives of medical science : AMS · 2019Article
- Combined Administration of Streptozotocin and Sucrose Accelerates the Appearance of Type 2 Diabetes Symptoms in Rats.Journal of diabetes research · 2019Article
- Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research.Nutrients · 2018Review
- Article
- Antidiabetic activity of extracts ofJournal of traditional and complementary medicine · 2017Article
- Liver mitochondrial membrane fluidity at early development of diabetes and its correlation with the respiration.Journal of bioenergetics and biomembranes · 2017Article
- Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract.BMC complementary and alternative medicine · 2016Article
- The Metabolic Responses to L-Glutamine of Livers from Rats with Diabetes Types 1 and 2.PloS one · 2016Article
- Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Review
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) generally follows prediabetes (PD) conditions such as impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Although studies reported an association of IGT or IFG with cataract, the experimental basis for PD associated cataract is not known. Hence, we evaluated neonatal streptozotocin (nSTZ) induced rat model to study PD associated cataractogenesis by injecting STZ to two-day old rats. While majority (70%) of nSTZ injected pups developed IGT (nSTZ-PD) by two months but not cataract even after seven months, remaining (30%) nSTZ rats developed hyperglycemia (nSTZ-D) by two months and mature cataract by seven months. Lens biochemical analysis indicated increased oxidative stress as indicated by increased SOD activity, lipid peroxidation, and protein carbonyl levels in nSTZ-D cataractous lens. There was also increased polyol pathway as assessed by aldose reductase activity and sorbitol levels. Though nSTZ-PD animals have not shown any signs of lenticular opacity, insolubilization of proteins along with enhanced polyol pathway was observed in the lens. Further there was increased oxidative stress in lens of IGT animals. These results suggest that oxidative stress along with increased polyol pathway might play a role in IGT-associated lens abnormalities. In conclusion, nSTZ-PD rat model could aid to investigate IGT-associated lens abnormalities.
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