Evidence map›Paper›PMID 25505900›Full record

ReviewFrontiers in immunology2014

The Role of microRNAs in Bovine Infection and Immunity.

Nathan Lawless, Peter Vegh, Cliona O'Farrelly, David J Lynn

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 63 citations in OpenAlex.

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  20. Bovine brucellosis - a comprehensive review.The veterinary quarterly · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nathan LawlessAnimal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Dunsany , Meath , Ireland ; School of Biochemistry and Immunology, Trinity College Dublin , Dublin , Ireland.
Peter VeghAnimal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Dunsany , Meath , Ireland ; School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin , Dublin , Ireland.
Cliona O'FarrellySchool of Biochemistry and Immunology, Trinity College Dublin , Dublin , Ireland.
David J LynnSouth Australian Health and Medical Research Institute, North Terrace , Adelaide, SA , Australia ; School of Medicine, Flinders University , Bedford Park, SA , Australia.
Trinity College Dublin · IEFlinders University · AUTeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the immune defense during infection is critical to understanding the etiology of the most prevalent bovine diseases. Here, we review current knowledge of miRNAs in the bovine genome, and discuss the advances in understanding of miRNAs as regulators of immune cell function, and bovine immune response activation, regulation, and resolution. Finally, we consider the future perspectives on miRNAs in bovine viral disease, their role as potential biomarkers and in therapy.

Indexed as

Bos taurusbovineimmune systemmicroRNAmiRNA

Identifiers

PMID25505900
PMCPMC4245999
OpenAlexW2168365587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.