ArticleInternational journal of bipolar disorders2013
Drug treatment patterns in bipolar disorder: analysis of long-term self-reported data.
Article in International journal of bipolar disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pooled it
- Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placebo-Controlled Clinical Trials.International journal of molecular sciences · 2016Pooled it
- Longitudinal Digital Mood Charting in Bipolar Disorder: Experiences with ChronoRecord Over 20 Years.Pharmacopsychiatry · 2023Article
- A retrospective study of psychotropic drug treatments in bipolar disorder at acute and maintenance episodes.Frontiers in psychiatry · 2023Article
- Review
- Correlates of Non-suicidal Self-Injury in Adolescent Psychiatric Patients in China.Frontiers in psychiatry · 2022Article
- Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study.Frontiers in psychiatry · 2022Article
- Patterns of Thyroid Hormone Prescription in Patients with Bipolar or Schizoaffective Disorder: Findings from the LiSIE Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- Frequency and correlates of violence against patients with schizophrenia living in rural China.BMC psychiatry · 2020Article
- Trajectories of adherence to mood stabilizers in patients with bipolar disorder.International journal of bipolar disorders · 2019Article
- Psychotropic medication treatment patterns in community-dwelling schizophrenia in China: comparisons between rural and urban areas.BMC psychiatry · 2019Article
- Regularity of self-reported daily dosage of mood stabilizers and antipsychotics in patients with bipolar disorder.International journal of bipolar disorders · 2018Article
- Electronic monitoring of self-reported mood: the return of the subjective?International journal of bipolar disorders · 2016Review
- Big data for bipolar disorder.International journal of bipolar disorders · 2016Review
- Daily mood monitoring of symptoms using smartphones in bipolar disorder: A pilot study assessing the feasibility of ecological momentary assessment.Journal of affective disorders · 2016Observational
- Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review.Neuropsychiatric disease and treatment · 2016Review
- Big data are coming to psychiatry: a general introduction.International journal of bipolar disorders · 2015Article
- Common use of dietary supplements for bipolar disorder: a naturalistic, self-reported study.International journal of bipolar disorders · 2015Article
- Searching the internet for health information about bipolar disorder: some cautionary issues.International journal of bipolar disorders · 2013Review
- Antidepressant dosage taken by patients with bipolar disorder: factors associated with irregularity.International journal of bipolar disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study is to investigate drug treatment patterns in bipolar disorder using daily data from patients who received treatment as usual.
methodsPatients self-reported the drugs taken daily for about 6 months. Daily drug use and drug combinations were determined for each patient, both by the specific drugs and by medication class. The drug load was calculated for all drugs taken within a medication class. RESULTS AND DISCUSSION: Four hundred fifty patients returned a total of 99,895 days of data (mean 222.0 days). The most frequently taken drugs were mood stabilizers. Of the 450 patients, 353 (78.4%) took a stable drug combination for ≥50% of days. The majority of patients were taking polypharmacy, including 75% of those with a stable combination. Only a small number of drugs were commonly taken within each medication class, but there were a large number of unique drug combinations: 52 by medication class and 231 by specific drugs. Eighty percent of patients with a stable combination were taking three or less drugs daily. Patients without a stable combination took drugs but made frequent changes. Taking more than one drug within a medication class greatly increased the drug load. To summarize, (1) patients were more likely to take a mood stabilizer than any other drug; (2) although most patients were taking polypharmacy, there were no predominant drug regimens even among those taking a stable combination; and (3) most patients with a stable combination take a relatively small number of drugs daily. The wide variation in drug regimens and numerous possible drug combinations suggest that more evidence is needed to optimize treatment of bipolar disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.