ArticleFrontiers in plant science2014
Comparative analysis of ABCB1 reveals novel structural and functional conservation between monocots and dicots.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Phylogenomic analysis of 20S proteasome gene family reveals stress-responsive patterns in rapeseed (Frontiers in plant science · 2022Pooled it
- Tandemly duplicated Rubisco activase genes of cereals show differential evolution and response to heat stress.Plant molecular biology · 2024Article
- Identification and mapping of QTLs and their corresponding candidate genes controlling high night-time temperature stress tolerance in wheat (Triticum aestivum L.).The plant genome · 2024Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Genome-wide investigation of ABCB, PIN, and AUX/LAX gene families and their involvement in the formation of leaf protrusions inFrontiers in plant science · 2024Article
- Comparative Study of Starch Phosphorylase Genes and Encoded Proteins in Various Monocots and Dicots with Emphasis on Maize.International journal of molecular sciences · 2022Article
- Structural and functional insights into the candidate genes associated with different developmental stages of flag leaf in bread wheat (Frontiers in genetics · 2022Article
- Article
- Genome-wide analysis of the HSP101/CLPB gene family for heat tolerance in hexaploid wheat.Scientific reports · 2020Article
- Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells.International journal of molecular sciences · 2020Article
- Molecular Characterization of Auxin Efflux Carrier- ABCB1 in hexaploid wheat.Scientific reports · 2019Article
- Genome-wide in silico identification of LysM-RLK genes in potato (Solanum tuberosum L.).Molecular biology reports · 2019Article
- A pathway-driven predictive model of tramadol pharmacogenetics.European journal of human genetics : EJHG · 2019Article
- Article
- Structural and functional evolution of an auxin efflux carrier PIN1 and its functional characterization in common wheat.Functional & integrative genomics · 2019Article
- Auxin Efflux Carrier ZmPGP1 Mediates Root Growth Inhibition under Aluminum Stress.Plant physiology · 2018Article
- Genome-wide analysis of the SPL/miR156 module and its interaction with the AP2/miR172 unit in barley.Scientific reports · 2018Article
- Genome-wide identification and characterization of gene family for RWP-RK transcription factors in wheat (Triticum aestivum L.).PloS one · 2018Article
- Evolution of Rubisco activase gene in plants.Plant molecular biology · 2018Article
- Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytohormone auxin plays a critical role in modulating plant architecture by creating a gradient regulated via its transporters such as ATP-binding cassette (ABC) B1. Except for Arabidopsis and maize, where it was shown to interrupt auxin transport, ABCB1's presence, structure and function in crop species is not known. Here we describe the structural and putative functional organization of ABCB1 among monocots relative to that of dicots. Identified from various plant species following specific and stringent criteria, ZmABCB1's "true" orthologs sequence identity ranged from 56-90% at the DNA and 75-91% at the predicted amino acid (aa) level. Relative to ZmABCB1, the size of genomic copies ranged from -27 to +1.5% and aa from -7.7 to +0.6%. With the average gene size being similar (5.8 kb in monocots and 5.7 kb in dicots), dicots have about triple the number of introns with an average size of 194 bp (total 1743 bp) compared to 556 bp (total 1667 bp) in monocots. The intron-exon junctions across species were however conserved. N-termini of the predicted proteins were highly variable: in monocots due to mismatches and small deletions of 1-13 aa compared to large, species-specific deletions of up to 77 aa in dicots. The species-, family- and group- specific conserved motifs were identified in the N-terminus and linker region of protein, possibly responsible for the specific functions. The near-identical conserved motifs of Nucleotide Binding Domains (NBDs) in two halves of the protein showed subtle aa changes possibly favoring ATP binding to the N-terminus. Predicted 3-D protein structures showed remarkable similarity with each other and for the residues involved in auxin binding.
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