ArticleFrontiers in microbiology2014
Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Next-generation anti-infective drugs in the post-antibiotic era: focusing on anti-virulence agents targeting the bacterial quorum sensing system.Frontiers in cellular and infection microbiology · 2026Review
- tesG expression as a potential clinical biomarker for chronic Pseudomonas aeruginosa pulmonary biofilm infections.BMC medicine · 2025Article
- Sodium houttuyfonate inhibits the cariogenic virulence ofJournal of oral microbiology · 2025Article
- Antibacterial activity and mechanism of Sodium houttuyfonate against heteroresistantFrontiers in microbiology · 2025Article
- Article
- Anti-Quorum-Sensing Potential of Ethanolic Extracts of Aromatic Plants from the Flora of Cyprus.Plants (Basel, Switzerland) · 2022Article
- Sodium houttuyfonate effectively treats acute pulmonary infection ofFrontiers in cellular and infection microbiology · 2022Article
- Effects of daphnetin on biofilm formation and motility ofFrontiers in cellular and infection microbiology · 2022Article
- Anti-quorum sensing evaluation of methyleugenol, the principal bioactive component, from theFrontiers in microbiology · 2022Article
- Review
- Traditional Chinese Medicine is an Alternative Therapeutic Option for Treatment ofFrontiers in pharmacology · 2021Review
- Effects of Natural Products on Bacterial Communication and Network-Quorum Sensing.BioMed research international · 2020Review
- Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors ofFrontiers in pharmacology · 2020Article
- Effects of sodium houttuyfonate on transcriptome of Pseudomonas aeruginosa.BMC research notes · 2019Article
- Study on Antibacterial and Quorum-Sensing Inhibition Activities ofMolecules (Basel, Switzerland) · 2019Article
- Anaerobiosis influences virulence properties of Pseudomonas aeruginosa cystic fibrosis isolates and the interaction with Staphylococcus aureus.Scientific reports · 2019Article
- Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlA in Pseudomonas aeruginosa.Molecular biology reports · 2019Article
- In-Silico Prediction and Modeling of the Quorum Sensing LuxS Protein and Inhibition of AI-2 Biosynthesis inMolecules (Basel, Switzerland) · 2018Article
- Anti-Biofilm and Antivirulence Activities of Metabolites fromFrontiers in microbiology · 2017Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quorum sensing (QS) is a means of cell-to-cell communication that uses diffusible signaling molecules that are sensed by the population to determine population density, thus allowing co-ordinate gene regulation in response to population density. In Pseudomonas aeruginosa, production of the QS signaling molecule, N-acyl homoserine lactone (AHL), co-ordinates expression of key factors of pathogenesis, including biofilm formation and toxin secretion. It is predicted that the inhibition of AHL sensing would provide an effective clinical treatment to reduce the expression of virulence factors and increase the effectiveness of antimicrobial agents. We previously demonstrated that sodium houttuyfonate (SH), commonly used in traditional Chinese medicine to treat infectious diseases, can effectively inhibit QS-regulated processes, including biofilm formation. Here, using a model system, we demonstrate that SH causes the dose-dependent inhibition of AHL production, through down-regulation of the AHL biosynthesis gene, lasI. Addition of SH also resulted in down-regulation of expression of the AHL sensor and transcriptional regulator, LasR, and inhibited the production of the QS-regulated virulence factors, pyocyanin and LasA. These results suggest that the antimicrobial activity of SH may be due to its ability to disrupt QS in P. aeruginosa.
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