ArticleAdvanced functional materials2014
High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials.
Article in Advanced functional materials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Advancements in hydrogel-based embolic agents: Categorized by therapeutic mechanisms.Cancer medicine · 2024Pooled it
- Bioengineered elastin- and silk-biomaterials for drug and gene delivery.Advanced drug delivery reviews · 2020Pooled it
- Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Novel Gene Synthesis Platform for Designing Functional Protein Polymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- Molecular simulations of the interfacial properties in silk-hydroxyapatite composites.Nanoscale · 2022Article
- Silk-Elastin-Like-Protein/Graphene-Oxide Composites for Dynamic Electronic Biomaterials.Macromolecular bioscience · 2022Article
- Recent Advances in Natural Materials for Corneal Tissue Engineering.Bioengineering (Basel, Switzerland) · 2021Review
- Dynamically tunable light responsive silk-elastin-like proteins.Acta biomaterialia · 2021Article
- Fibrous Scaffolds From Elastin-Based Materials.Frontiers in bioengineering and biotechnology · 2021Review
- Stimuli-responsive composite biopolymer actuators with selective spatial deformation behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Smart Material Hydrogel Transfer Devices Fabricated with Stimuli-Responsive Silk-Elastin-Like Proteins.Advanced healthcare materials · 2020Article
- Self-assemble peptide biomaterials and their biomedical applications.Bioactive materials · 2019Review
- Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties.Journal of functional biomaterials · 2019Article
- Fabrication and Characterization of Recombinant Silk-Elastin-Like-Protein (SELP) Fiber.Macromolecular bioscience · 2018Article
- Silkworm silk-based materials and devices generated using bio-nanotechnology.Chemical Society reviews · 2018Review
- Responsive Protein Hydrogels Assembled from Spider Silk Carboxyl-Terminal Domain and Resilin Copolymers.Polymers · 2018Article
- Unraveling the Molecular Mechanisms of Thermo-responsive Properties of Silk-Elastin-Like Proteins by Integrating Multiscale Modeling and Experiment.Journal of materials chemistry. B · 2018Article
- Critical factors for the bulk adhesion of engineered elastomeric proteins.Royal Society open science · 2018Article
- Silk Materials Functionalized via Genetic Engineering for Biomedical Applications.Materials (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The need for dynamic, elastomeric polymeric biomaterials remains high, with few options with tunable control of mechanical properties, and environmental responses. Yet the diversity of these types of protein polymers pursued for biomaterials-related needs remains limited. Robust high-throughput synthesis and characterization methods will address the need to expand options for protein-polymers for a range of applications. To address this need, a combinatorial library approach with high throughput screening is used to select specific examples of dynamic protein silk-elastin-like polypeptides (SELPs) with unique stimuli responsive features, including tensile strength, and adhesion. Using this approach 64 different SELPs with different sequences and molecular weights are selected out of over 2,000 recombinant E. coli colonies. New understanding of sequence-function relationships with this family of proteins is gained through this combinatorial-screening approach and can provide a guide to future library designs. Further, this approach yields new families of SELPs to match specific material functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.