ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
GABAergic projections from the medial septum selectively inhibit interneurons in the medial entorhinal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 80 citations in OpenAlex.
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- A septo-entorhinal GABAergic pathway that enables switching between episodic memories.Nature neuroscience · 2026Article
- Optogenetic Stimulation of CA1 Pyramidal Neurons at Theta Enhances Recognition Memory in Brain Injured Animals.Journal of neurotrauma · 2023Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Septo-hippocampal dynamics and the encoding of space and time.Trends in neurosciences · 2023Review
- Simulation of oscillatory dynamics induced by an approximation of grid cell output.Reviews in the neurosciences · 2023Review
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- Article
- Age-related changes in medial septal cholinergic and GABAergic projection neurons and hippocampal neurotransmitter receptors: relationship with memory impairment.Experimental brain research · 2022Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Medial septum: relevance for social memory.Frontiers in neural circuits · 2022Review
- Precisely timed theta oscillations are selectively required during the encoding phase of memory.Nature neuroscience · 2021Article
- Review
- Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.Brain : a journal of neurology · 2021Article
- Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells.Science advances · 2021Article
- Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice.International journal of molecular sciences · 2021Article
- A Characterization of the Electrophysiological and Morphological Properties of Vasoactive Intestinal Peptide (VIP) Interneurons in the Medial Entorhinal Cortex (MEC).Frontiers in neural circuits · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons project from the MS to the MEC, their synaptic targets are unknown. To investigate whether MS neurons innervate specific layers and cell types in the MEC, we expressed channelrhodopsin-2 in mouse MS neurons and used patch-clamp recording in brain slices to determine the response to light activation of identified cells in the MEC. Following activation of MS axons, we observed fast monosynaptic GABAergic IPSPs in the majority (>60%) of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons in all layers of the MEC, but in only 1.5% of nonstellate principal cells (NSPCs) and in no stellate cells. We also observed fast glutamatergic responses to MS activation in a minority (<5%) of NSPCs, FS, and LTS interneurons. During stimulation of MS inputs at theta frequency (10 Hz), the amplitude of GABAergic IPSPs was maintained, and spike output from LTS and FS interneurons was entrained at low (25-60 Hz) and high (60-180 Hz) gamma frequencies, respectively. By demonstrating cell type-specific targeting of the GABAergic projection from the MS to the MEC, our results support the idea that the MS controls theta frequency activity in the MEC through coordination of inhibitory circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.