ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Modality-spanning deficits in attention-deficit/hyperactivity disorder in functional networks, gray matter, and white matter.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 87 citations in OpenAlex.
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- Altered intrinsic connectivity in default mode and somatomotor networks in children and adolescents with ADHD: a neuroimaging meta-analysis.European child & adolescent psychiatry · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Correlation of altered intrinsic functional connectivity with impaired self-regulation in children and adolescents with ADHD.European archives of psychiatry and clinical neuroscience · 2025Article
- The Significance of a Higher Prevalence of ADHD and ADHD Symptoms in Children Who Stutter.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Functional connectivity and complexity analyses of resting-state fMRI in pre-adolescents demonstrating the behavioral symptoms of ADHD.Psychiatry research · 2024Article
- Cortical structural and functional coupling during development and implications for attention deficit hyperactivity disorder.Translational psychiatry · 2023Article
- Microstructure abnormalities of the diffusion quantities in children with attention-deficit/hyperactivity disorder: an AFQ and TBSS study.Frontiers in psychiatry · 2023Article
- Normative model detects abnormal functional connectivity in psychiatric disorders.Frontiers in psychiatry · 2023Article
- ADHD and its neurocognitive substrates: A two sample Mendelian randomization study.Translational psychiatry · 2022Article
- Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control.Developmental cognitive neuroscience · 2022Article
- Functional brain connectomes reflect acute and chronic cannabis use.Scientific reports · 2022Article
- An examination of the relationships between attention/deficit hyperactivity disorder symptoms and functional connectivity over time.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Beyond massive univariate tests: Covariance regression reveals complex patterns of functional connectivity related to attention-deficit/hyperactivity disorder, age, sex, and response control.Biological psychiatry global open science · 2022Article
- Riemannian Geometry of Functional Connectivity Matrices for Multi-Site Attention-Deficit/Hyperactivity Disorder Data Harmonization.Frontiers in neuroinformatics · 2022Article
- Alterations in Structural and Functional Connectivity in ADHD: Implications for Theories of ADHD.Current topics in behavioral neurosciences · 2022Review
- Increased integration between default mode and task-relevant networks in children with ADHD is associated with impaired response control.Developmental cognitive neuroscience · 2021Article
- Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders.Nutrients · 2021Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Previous neuroimaging investigations in attention-deficit/hyperactivity disorder (ADHD) have separately identified distributed structural and functional deficits, but interconnections between these deficits have not been explored. To unite these modalities in a common model, we used joint independent component analysis, a multivariate, multimodal method that identifies cohesive components that span modalities. Based on recent network models of ADHD, we hypothesized that altered relationships between large-scale networks, in particular, default mode network (DMN) and task-positive networks (TPNs), would co-occur with structural abnormalities in cognitive regulation regions. For 756 human participants in the ADHD-200 sample, we produced gray and white matter volume maps with voxel-based morphometry, as well as whole-brain functional connectomes. Joint independent component analysis was performed, and the resulting transmodal components were tested for differential expression in ADHD versus healthy controls. Four components showed greater expression in ADHD. Consistent with our a priori hypothesis, we observed reduced DMN-TPN segregation co-occurring with structural abnormalities in dorsolateral prefrontal cortex and anterior cingulate cortex, two important cognitive control regions. We also observed altered intranetwork connectivity in DMN, dorsal attention network, and visual network, with co-occurring distributed structural deficits. There was strong evidence of spatial correspondence across modalities: For all four components, the impact of the respective component on gray matter at a region strongly predicted the impact on functional connectivity at that region. Overall, our results demonstrate that ADHD involves multiple, cohesive modality spanning deficits, each one of which exhibits strong spatial overlap in the pattern of structural and functional alterations.
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